Abstract P2027: Associations Between Paraben Exposure and Cardiometabolic Outcomes in Pediatric Populations: A Systematic Review
Notice bibliographique
Résumé
Introduction: Parabens are antimicrobial chemicals frequently used as preservatives in consumer products. Due to their chemical structure, exposure to parabens may impact cardiometabolic health by disrupting specific biological pathways. Objective: To synthesize the literature on the associations between paraben exposure and cardiometabolic outcomes in pediatric populations. Methods: Scopus, PubMed, Web of Science, and Embase databases were systematically searched for studies published before July 2024. Inclusion criteria were: at least one paraben exposure measure, at least one reported cardiometabolic outcome (excluding adiposity), and published in English or French. Data extraction included: demographic and methodological details and estimated associations between parabens and cardiometabolic outcomes. Quality was assessed using the Quality Assessment Tool for Quantitative Studies which was developed by the Effective Public Health Practice Project. Results: Of the 9595 records identified: 935 were duplicates, 14 were retained in full-text, and five were included in the review. Excluded were: non-human studies, populations outside the age range of interest (3-19 years), or missing relevant exposure or outcome measures. All five studies were cross-sectional, including 4 of moderate and 1 of weak quality. Exposures studied included methyl (n=5), ethyl (n=5), propyl (n=5), butyl (n=4), and the sum of parabens (n=2), Outcomes studied included blood pressure (n=3), blood lipids (n=3), and measures of glucose and insulin indices (n=3). Confounders adjusted for in most studies included age, sex, socioeconomic status, physical activity, ethnicity, and smoking. Statistical methods included: linear regression models (n=3), Wilcoxon and Chi-squared tests (n=1) and Bayesian machine kernel regression (n=1). Study heterogeneity limited synthesis of study results. One study reported negative associations between ethyl paraben exposure and measures of blood pressure in children 4-6. One study reported a positive association between parabens (in a chemical mixture) and triglyceride/HDL ratios in adolescents. The remaining studies reported no meaningful associations. Conclusion: Research on this topic is limited and heterogeneous making findings inconsistent and difficult to interpret. There is a need for longitudinal studies on parabens and cardiometabolic health, and for a greater understanding of the relationship between lifestyle and exposure patterns in youth.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».