Abstract 5629: TEQ103, a novel therapeutic for the treatment of estrogen receptor alpha positive (ERα+) breast cancer
Notice bibliographique
Résumé
Abstract Background: Breast cancer is the most prevalent female cancer. Approximately 75% of them are ERα+ and are treated with ERα targeting agents. However, a good portion will ultimately relapse. TEQ103 (Sera2, ErSO-TFPy) is a first-in-class small molecule acting through the anticipatory unfolded protein response (aUPR) following dysregulation of calcium homeostasis in ERα+ tumor cells. The goal of this work is to further evaluate the efficacy, the influence of schedules of administration and the pharmacokinetics (PK) of TEQ103. Methods: TEQ103 was evaluated IV in advanced stage human breast adenocarcinoma MCF-7 implanted in athymic female mice. Mice with approximately 500mm3 tumors were randomized and 2 schedules evaluated, daily x 10, (0, 1, 2, 4, 15 & 30mg/kg/injection), and intermittent on day1 & 10, (1, 5, 20, 75 & 150mg/kg/injection), 9 mice/group. Tumors were measured with a caliper and efficacy endpoints included tumor growth delay (TGD), complete regressions (CR), and Tumor Free Survivors (TFS). PK evaluation was performed post one IV administrations at 5, 20 & 75mg/kg (6 mice/ dose) over 8 hours in plasma, at 4 and 8h post injection in tumors, and at a late 10 day sampling in both matrices. Plasma and tumor concentrations were measured using LC-MS/MS SCIEX QTRAP 6500+ and PK parameters in plasma were determined using noncompartmental methods (Kinetica Software v5.1). Results: TEQ 103 was found highly active in MCF-7 tumor bearing mice with a large therapeutic index. With the daily schedule, the lowest active dose was 2mg/kg/injection (i.e., 20mg/kg total dose (TD)) with 2/9 TFS and 44 days TGD for the 7 relapsing mice. With the intermittent schedule, the lowest active dose was 5mg/kg/injection (10mg/kg TD) with 4/9 TFS and 56 days TGD for the 5 relapsing mice. At total dosages equal and above 40mg/kg TD, both schedules lead to 100% TFS (CRs lasted 121 days post tumor induction). This indicates that TEQ103 is schedule independent. Overall TEQ103 was well tolerated and did not induce body weight loss in the dose ranges studied. PK profiles in plasma showed biphasic kinetics of TEQ103 in MCF-7 bearing mice. The Cmax and AUC0-8h increase was approximately dose-proportional over the dose range studied. The 4h concentrations in plasma and tumor at 5, 20 and 75 mg/kg were 7.25, 16.7 and 178 ng/mL and 582, 1796 and 5709 ng/g, respectively. There was a very good tumor retention with levels of TEQ 103 detectable 10 days post treatment with 75mg/kg dose. Conclusion: These results demonstrate the significant durable antitumor effect of TEQ103 driven by the total dose administered regardless of schedule of administration, the wide therapeutic index and the concentration in the tumor tissue at levels markedly above the nM IC50 reached in vitro. These studies form the basis for PKPD Tumor Growth Inhibition modeling that will be used for projection of an efficacious starting dose in a subsequent breast cancer patients’ phase 1 clinical trial. Citation Format: Marie-Christine Bissery, Eef Hoeben, Elisabeth Bertrand, Sylvie Maubant, Maëva Albanese, Olivier Duchamp, Isabelle St-Jean, Mads K. Dalsgaard. TEQ103, a novel therapeutic for the treatment of estrogen receptor alpha positive (ERα+) breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 5629.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».