(160) NON-GENITALLY STIMULATED ORGASMS (NGSOS) INCREASE PLASMA PROLACTIN IN A POST-MENOPAUSAL WOMAN
Notice bibliographique
Résumé
Abstract Introduction Sexual orgasm is a complex, multimodal reflex induced typically by genital stimulation. Such stimulation activates excitatory neurochemical pathways in the brain and spinal cord that ultimately stimulate sympathetic outflow. In women, this can be achieved by stimulation of the external and internal clitoris, anterior cervix, nipples, and other erogenous zones in sensitized individuals. Although the reflex is a product of “bottom-up” genitosensory stimulation, it is also controlled by “top-down” processing of excitation and inhibition that controls both the timing of parasympathetic and sympathetic blood flow, and the subjective ability to “let go” into the orgasm when it is imminent. Indeed, orgasms activate cortical, limbic, hypothalamic, and brainstem structures, have characteristic pelvic floor muscle signatures and spinal cord activation that characterizes sexual “climax”, and can be rated subjectively in terms of the quality and type of sensory stimulation, affective experience, and the evaluation of pleasure. Orgasms are also accompanied by neurochemical and endocrine changes that characterize ecstatic pleasure, satiety, and refractoriness. Among these correlates is a consistent, orgasm-induced surge of prolactin released from the anterior pituitary into the peripheral bloodstream due to an immediate inhibition of dopamine. Orgasms can also be induced without genital stimulation. People experience orgasms during sleep or after exercise. Some women can have orgasms simply by engaging in imagery and fantasy. Paraplegic men and women also report “phantom” orgasms. This suggests that top-down control of orgasm can be activated on its own. Objective Women with Tantric experience can give themselves orgasms of different durations. In one report, these resulted in lawful increases in plasma prolactin. Here we examined prolactin and pelvic floor contractions in a surgically menopausal woman who has developed a systematic methodology to induce NGSOs by sensitized pelvic floor movements. Methods Blood was obtained before, immediately after, and 15 min after either a 2.5-min or 10-min NGSO, or a control condition (10 min Pilates workout). Plasma was assayed for prolactin, luteinizing hormone, follicle-stimulating hormone, and total testosterone. The woman also recorded her pelvic floor movements during a separate 10-min NGSO. Importantly, the woman was fully clothed during the NGSOs, and used only her pelvic floor movements without any tactile stimulation of the clitoral glans. Results Plasma prolactin increased to 109 and 141% of baseline immediately after the 2.5 min and 10 min NGSO. In contrast, the 10-min Pilates workout decreased plasma prolactin levels to 88% of baseline. Changes in LH, FSH, and total T were not significant. Characteristic pelvic floor contractions of orgasm came at approximately 20-sec intervals and were preceded by a sensitizing set of small contractions that built in intensity. Conclusions NGSOs induced by systematic and reproducible training of the pelvic floor represent a new vista in the study of women’s orgasms and a potential therapeutic intervention for women with orgasm difficulties. Disclosure Any of the authors act as a consultant, employee or shareholder of an industry for: Consultant: FirmTech Inc. (USA); Kanna Health Ltd. (UK); Ovoca Bio/IVIX Corp. (Ireland); Reunion Neuroscience (Canada); SmartBod/Lioness, Inc. (USA); Vella Bioscience (USA).
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».