Clinical Validation of the Tremoflo C2 Versus Tremoflo C100 in Asthmatic Patients 2-7 Years of Age
Notice bibliographique
Résumé
Abstract Rationale: Current asthma guidelines recommend spirometry for asthma diagnosis and management, although difficult in young children due to the effort-dependent maneuver. Airwave oscillometry system (AOS) is a non-invasive and effort-independent device that measures resistance and reactance from a range of frequencies and effective in assessing central and peripheral airways. Tremoflo C2 (Thorasys Inc., Montreal, Canada), which is a succession to Tremoflo C100, is smaller in size and weight, works wirelessly, and has a novel built-in user interface. The objectives are to determine the agreement between C2 and C100, demonstrate the validity of the current reference equation and several parameters that identify uncontrolled asthma, and evaluate the feasibility of two devices. Methods: We evaluated 53 patients aged 2-7 years of age with physician diagnosed asthma in the Allergy and Immunology outpatient clinic at Children's Hospital of Orange County (CHOC) from September 2023 to November 2023. Asthma severity and control were assessed using current asthma guideline criteria. Tremoflo AOS C2 and C100 were used to obtain three sets of valid measurements at mutually prime frequencies from 7 hertz (Hz) to 41 Hz. Four oscillometry metrics (R7, R7-19, AX, and X7) were measured and calculated. Bland-Altman plots were utilized to evaluate proportional bias. Using reference equations by Ducharme et al., small airway dysfunction (SAD) was defined as z-scores exceeding 1.645 residual standard deviation (RSD). After completion, feedback was provided by patients and operators. Results: Although 62.3% of patients were 5-7 years of age, 37.7% were 2-4 years, male gender, 84.9% having mild asthma severity, and 86.8% well-controlled. Overall intraclass correlation (ICC) showed good agreement (.80 in R7, R7-19, X7, and AX. Of the four major metrics, proportional bias was only seen for R7-R19 (p=.017). As the average R7-R19 metric increased, the difference between C2 and C100 also increased. There was no significant difference in SAD percentage between C2 and C100 throughout different patient characteristics. Survey results from both patients and operators were favorable for C2 given its small size and user-friendly interface. Conclusion: In our predominantly well-controlled, mild asthmatic population, there was good agreement for resistance and reactance values between the C2 and C100. Both devices demonstrated the validity of the current reference equation in patients and identified SAD even in patients that were diagnosed as well-controlled. All 53 participants were able to perform both devices, including the younger population. Both C2 and C100 were feasible with favorable feedback for C2.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,004 | 0,010 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».