Findings in Chest Images of Children With Systemic Lupus Erythematosus
Notice bibliographique
Résumé
Abstract Systemic lupus erythematosus (SLE) is a chronic systemic disease associated with high morbidity and mortality that can affect the lungs with varying degrees of severity. Therefore, it is crucial to understand the imaging patterns that can be found in chest CT scans of children with SLE. Our objective is to describe the findings in chest CT of patients diagnosed with SLE who were treated at HOMI from 2022 to 2024.An observational, descriptive, cross-sectional study was conducted. All patients aged 0 to 18 years diagnosed with SLE and treated at HOMI (a fourth-level hospital in Bogotá, Colombia) between 2022 and 2024, who underwent a chest CT, were screened. Qualitative variables were analyzed using frequency and percentage, and quantitative variables were analyzed using medians and interquartile ranges due to their non-normal distribution.Among two hundred and twenty patients screened, 25 patients with pulmonary involvement were included. The median was 15 years and 96% were female. Forty percent required hospitalization and management in intermediate care or the ICU. Rhinoenterovirus was isolated in 2 out of 6 patients in whom a filmarray was performed. A chest X-ray was conducted in 87.5% of the children. Atelectasis were reported in 48% of these cases, and ground-glass opacities were seen in 28%. Additionally, 20% had pleural effusion.Atelectasis were evident in 60% of chest CT scans. Pleural effusions and ground-glass opacities were observed in 32% and 28%, respectively. Consolidation, micronodules, and intrapulmonary lymph nodes were found 16% of the images. Granulomas and alveolar hemorrhages were evident in 8%. Only one patient had a normal image. Twenty-four patients had a complete blood count, 48% exhibited anemia, 32% had thrombocytopenia, and 48% had lymphopenia. Children with lymphopenia showed less consolidations compared to those with normal leukocytes (4 vs. 0 patients), with statistical significance (p = 0.047).Our cohort demonstrates that pediatric patients with SLE and pulmonary compromise can present with a wide variety of imaging findings. However, the significance of these findings are not well defined in the literature. For instance, atelectasis, although unspecific, was the most common finding in hospitalized patients, indicating central airway compromise. Pleural effusions were also frequently observed given the well-known pathophysiology of SLE. This study emphasizes the need for further evaluation of the significance and prognostic implications of imaging findings, and the prompt evaluation by a pulmonologist in children with SLE presenting with respiratory symptoms.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».