Association of Lung Computed Tomography High Attenuation Areas With Physiological Exercise Measures
Notice bibliographique
Résumé
Abstract Rationale: Interstitial lung abnormalities (ILAs) are incidental imaging findings thought to be precursors of interstitial lung diseases (ILDs). Computed tomography (CT)-based assessments of high-attenuation areas (HAAs) in the lungs may help identify adults at higher risk of developing ILAs. ILAs and HAAs have been linked to lower forced vital capacity (FVC), diminished self-reported health status, and greater overall risk of mortality, but little is known about their association with exercise function. This study aims to investigate whether a heightened burden of HAA on CT is associated with impaired exercise capacity in a community-based cohort. Methods: This observational cross-sectional study used data from the Canadian Cohort of Obstructive Lung Disease (CanCOLD) registry, a community-based sample of participants. Lung function and cardiopulmonary exercise testing (CPET) were performed using American Thoracic Society standards. Participants underwent inspiratory full-lung CT on helical scanners, following a standardized protocol (100 kVp, 1.00-1.25 mm slice thickness, and 0.5 s rotation time). HAA was defined as percent of lung volume with Hounsfield units between -600 and -250. Logarithmic transformation was applied to HAA to enhance normalization. Exercise measures of interest included work rate (watts/min), metabolic rate of oxygen consumption (VO2, L/min), oxygen saturation (%), and dyspnea (Borg 0-10 scale). Linear regression was performed to evaluate the correlation between log HAA and peak exercise measures, and adjusted for confounders (age, sex, height, and weight). Results: There were 1,177 participants from the CanCOLD cohort included in this study. The mean age was 66.6 ± 9.8 years, 683 (58%) participants were male, and 1,119 (95.1%) were of White European ancestry. Higher percentages of HAA were associated with significantly lower work rate (β coefficient -16.96; CI -23.36 to -10.55) and VO2 (β coefficient = -0.26; CI -0.35 to -0.16) at peak exercise (Figure 1). These associations remained statistically significant after adjusting for confounders. Oxygen saturation and dyspnea measures were not associated with HAA burden (β = 0.30; CI -0.22 to 0.83 and β = -0.04; CI -0.53 to 0.46, respectively). Conclusions: Burden of HAA on CT was significantly associated with peak exercise work rate and metabolic rate of oxygen consumption, though it does not exhibit a correlation with oxygen saturation or dyspnea. Further research should assess key risk factors (e.g., smoking and COPD) to more accurately determine how a heightened burden of HAA correlates with impaired exercise capacity. Understanding this association could help better identify high-risk adults and facilitate ILA and ILD detection.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».