The Modified Functional Status Questionnaire for Assessing Patients with Parkinson’s Disease Psychosis Treated with Pimavanserin: A Post Hoc Analysis
Notice bibliographique
Résumé
Over half of patients with Parkinson’s disease experience psychosis (PDP) symptoms over the course of their disease. In addition to significantly impacting patients’ health-related quality of life and cognitive abilities, these symptoms impact patients’ activities of daily living (ADLs) and overall functional status. Clinical assessment of how psychosis impacts these measures is crucial; however, few studies have assessed functional status among patients with PDP. A previous phase 4 study assessing the impact of pimavanserin on ADLs in patients with PDP demonstrated that a modified version of the Functional Status Questionnaire (mFSQ) could be used for this purpose. This post hoc analysis aimed to demonstrate the utility of the mFSQ as a patient-reported outcomes tool and to expand on initial study findings by showing the impact of pimavanserin on ADLs and functional status for each mFSQ subscale. An analysis of mFSQ data was conducted on patients with PDP treated with pimavanserin. This analysis evaluated the least-squares mean (LSM) change from baseline to week 16 on the mFSQ by subscale (basic ADL, intermediate ADL, psychological function, quality of interaction, and social activity). Pearson’s correlation was used to assess the relationship between results from the mFSQ and the well-established Schwab and England ADL scale. In this assessment (n = 29), treatment with pimavanserin was associated with improvements on all 5 domains of the mFSQ, highlighting a broad improvement in ADLs and function. The greatest LSM (SE) improvement was seen in the social activity subscale [25.8 (7.52); 95% CI 10.2–41.5; p = 0.0026]. The mFSQ results demonstrated positive correlations with patient- and caregiver-rated Schwab and England ADL scales. This analysis provides additional information about the impact of treatment with pimavanserin on specific mFSQ subscales. Additionally, the mFSQ was significantly correlated with the patient- and the caregiver-rated Schwab and England ADL scales. Approximately half of all patients with Parkinson’s disease experience hallucinations or delusions. These are symptoms of a condition known as Parkinson’s disease psychosis (PDP). PDP impacts patients’ activities of daily living (ADLs) and functioning. Pimavanserin is an antipsychotic medication used to treat hallucinations and delusions associated with PDP. A previous study demonstrated that a newer, self-administered questionnaire called the modified Functional Status Questionnaire (mFSQ) can be used to evaluate ADLs and functioning in patients with PDP. The current analysis aims to understand the impacts of pimavanserin on ADLs and functioning, including physical health, psychological well-being, and social activity. We measured these using 5 parts (known as “subscales”) of the mFSQ. We used data from a previous study of 29 patients with PDP. Patients were treated with pimavanserin for 16 weeks. We measured changes in the 5 mFSQ subscales before and after treatment. We also measured how well the mFSQ results agreed with the results of another, well-established questionnaire (called the Schwab and England ADL scale) that also evaluates how well patients perform ADLs and was completed by the patients and caregivers. Treatment with pimavanserin was associated with improvements on all 5 subscales of the mFSQ. The greatest improvements were in the social activity subscale. We also found good agreement between the mFSQ and the well-established Schwab and England ADL scale, which supports the usefulness of the mFSQ in measuring ADLs and functioning in patients with PDP. This analysis is important because it provides additional information about the benefit of pimavanserin on ADLs and functioning.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
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