0134 Sex Differences in Circadian-linked and Learning Behaviors Among Mice in Socially-housed Automated Home Cages
Notice bibliographique
Résumé
Abstract Introduction Women often report more sleep and circadian misalignment due to biological (e.g., hormones) and/or social (e.g., scheduling demands) factors. Mice are effective model organisms to assess circadian-linked behaviors associated with learning and human sleep due to similarities in sleep cycles. Singly-housed female mice are reported to spend more time awake than male mice and perform learning tasks differently. Despite mice being innately social animals, limited research exists examining circadian-linked behavior in socially-housed mice. Automated home cages allow for continuous monitoring of mice across the circadian cycle. In this study, we aimed to use an automated home cage with socially housed mice to provide naturalistic representation of mouse circadian-linked and learning behaviors that may represent underlying sex differences in human sleep and circadian rhythms. Methods We investigated sex differences in the circadian-linked and learning behaviors between male and female mice. Seventeen socially-housed C57BL/6J mice (9 Male; 8 Female) were continuously monitored using the TSE Intelligcage system. Mice were monitored across 15 days (12:12 light-dark cycle). Animals and cage-interactions (i.e., corner visits indicating circadian-activity; nosepokes indicating learning; and water licks indicating learning) were individually tracked. Water ports with various restrictions (e.g., nosepokes; restricted corner access) assessed learning. We created actograms and learning graphs by tracking mouse interactions and conducted independent sample t-tests to compare both sexes over time and for four hours of diurnal activity each day. Results Both sexes displayed more nocturnal than diurnal activity and biphasic activity. Across the 24-hour day, sex differences emerged with visit durations (females=longer, p< 0.01), licking (males=more, p< 0.01) and lick duration (males=longer, p< 0.001). During the day (rest), females demonstrated higher nosepokes (p< 0.01), visits (p=0.02), and licking (p< 0.01) than males. Females also demonstrated lower accuracy for water port visits (p< 0.05), though total visits considered accurate were comparable to males. Conclusion Consistent with disturbed sleep in women, female mice demonstrated more daytime activity. Differences in female circadian-linked behaviors may indicate biological basis for higher frequencies of some sleep and circadian disorders among women compared to men. Female mice appeared to exhibit more exploratory learning behaviors, but learning based on accuracy was otherwise comparable between sexes. Support (if any)
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».