Green Synthesis of Iron Nanoparticles Using Gum Arabic (Acacia senegal): Antimicrobial, Anticoagulant, and Wound-Healing Applications
Notice bibliographique
Résumé
Recently, iron nanoparticles (FeNPs) synthesized using gum arabic as a green reducing agent have demonstrated significant biological activity, highlighting the potential of nanotechnology in biomedical applications.The FeNPs were prepared by dissolving 4.04 g of iron nitrate [Fe(NO)9HO] in 100 mL of deionized water, heating the solution to 60 for 1 hour, and then mixing it with 10 mL of plant extract.The color of the solution turned reddish brown, confirming the formation of nanoparticles.The biocompatibility of FeNPs, along with their antimicrobial, anticoagulant, and wound-healing activities, suggests their potential applications in healthcare.The antimicrobial properties of FeNPs were evaluated against several bacterial strains, including Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, and Pseudomonas aeruginosa.The results showed that the nanocomposite exhibited significant inhibitory effects against Staphylococcus species, with inhibition rates ranging from 61.96% to 77.82% across various concentrations.These findings suggest that FeNPs inhibited biofilm formation in Staphylococcus species, which were the most sensitive bacteria tested, in a concentrationdependent manner.This suggests that FeNPs could serve as a suitable replacement for conventional antibacterial substances, especially for infections that involve biofilms.The anticoagulant activity of FeNPs was assessed by measuring prothrombin time (PT) and partial thromboplastin time (PTT) at concentrations ranging from 50 to 100 g/mL.A marked increase in clotting time was observed, indicating strong anticoagulant effects.The greatest delay in clotting was observed at the concentration of 100 g/mL.This effect is attributed to the interaction of FeNPs with key coagulation factors (VIII, IX, and XI), which delays thrombin formation and alters fibrin production.Additionally, Fe NPs generate reactive oxygen species (ROS) that influence platelet activity, further aiding in the prevention of blood clots.FeNPs were shown to accelerate fibroblast migration and collagen synthesis during the wound healing process.The treated group exhibited a significantly higher rate of scratch closure (~88%) compared to the untreated group (~78%) after 72 hours.FeNPs were shown to accelerate fibroblast migration and collagen synthesis during the wound healing process.The treated group exhibited a significantly higher rate of scratch closure (~88%) compared to the untreated group (~78%) after 72 hours.Moreover, these particles are also capable of inducing angiogenesis and activating the immune system.The gum Arabic-synthesized Fe NPs exhibited strong antimicrobial, anticoagulant, and wound-healing activities, demonstrating their high potential in biomedical applications.Further studies are required to optimize their efficacy and safety for use in patient care settings.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».