ELUCIDATING COGNITIVE IMPAIRMENT IN CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS
Notice bibliographique
Résumé
PV158 / #289 Poster Topic: AS18 - Pediatric SLE Background/Purpose Childhood-onset systemic lupus erythematosus (cSLE) is characterized by a more severe disease and a high frequency of neuropsychiatric manifestations. Especially cognitive impairment (CI) is observed in around 40% of cSLE patients and associated with worse outcome in adult life. Here, we aimed to pursue the associations among serum cytokines, anti-P antibodies, the NMDA receptor antibodies, magnetic resonance imaging findings in cSLE patients with or without CI. Methods We did a cross-sectional study including consecutive cSLE patients with well characterized clinical and laboratory data. We evaluated CI through Pediatric-Automated Neuropsychological Assessment Metrics (Ped-ANAM). All included subjects had MRI performed with a 3T Philips Achieva (Best, The Netherlands). Sagittal T1-weighted images (3-dimensional acquisitions obtained in the sagittal T1-weighted gradient echo plane with 1 mm thickness, an angle of excitation of 35, a repetition time of 22 ms, a time to echo of 9 ms, a matrix of 240 × 240 pixels, a field of view of 230 × 250 cm, 1 × 1 pixel). MRI were analyzed using FreeSurfer and volBrain softwares. The concentration of cytokines was determined by Luminex immunoassay (MILLIPLEX map Human High Sensitivity T Cell Panel, Millipore, USA) according to the manufacturer’s protocol. The limit of detection was 0.48pg/mL for IFN-gamma, 1.12pg/mL for IL-4, 0.11pg/mL for IL-6, 0.56pg/mL for IL-10, 0.15pg/mL for IL-12 (p70) and 0.16pg/mL for TNF. When the concentration was undetectable, it was attributed the half of these values for statistical purposes. The concentration of NMDA NR-2 subunit receptor was determined by Enzyme-Linked Immunosorbent Assay (ELISA, Mybiosource, CA, USA) according to the manufacturer’s protocol, with the limit of detection of 0.09 ng/mL. The presence of anti-P was determined by Enzyme-Linked Immunosorbent Assay (ELISA, Quanta Lite™ Ribosome P, Ivona, CA, USA) according to the manufacturer’s protocol, and samples were classified as negative or positive. The Statistical Package for the Social Sciences software (IBM SPSS, version 22) was used for analysis. Results Eighty-five cSLE patients were included. There was no significant difference regarding the dosages of cytokines, NR-2 and anti-P in patients with or without CI. Patients with CI had impaired scores on 8 subtests and 3 indexes from Ped-ANAM. Also, the volumes of Central (p=0.035) and Mid Anterior (p=0.016) Corpus Callosum were significantly lower in the group with CI (p=0.045). NR-2 concentration correlated inversely with SLEDAI scores (p=0.021) and with the Cornu Ammonis 1 (CA1) volume (p=0.029). IL-4 correlated inversely with the Ped-ANAM scores (p=0.033), IL-10 correlated inversely with Total CA2 CA3 (p=0.012) and right CA2 CA3 volumes (p=0.014) and directly with Left Caudate volume (p=0.026). Also, IL-6 correlated inversely with Right CA2 CA3 volume (p=0.047). Conclusions Simple reaction time and procedural reaction time were the cognitive domains more often affected in cSLE patients with CI. We observed a significant reduction of corpus callosum and hippocampal subfields in cSLE associated with the presence of NR2 and inversely with IL6, suggesting that autoantibodies and cytokines may be associated with structural brain abnormalities and CI in cSLE.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».