Periodic leg movements and cognitive function in middle-aged and elderly adults with mediating role of REM duration and PLMS-related arousal
Notice bibliographique
Résumé
The relationship between periodic leg movements of sleep (PLMS) and cognitive function is controversial. This study aims to explore: (1) the effects of PLMS on cognitive function in middle-aged and elderly patients; and (2) the mediating role of rapid eye movement (REM) sleep duration and PLMS-related arousal between PLMS and cognitive performance. This retrospective study was conducted based on inpatient medical records. Middle-aged and elderly patients hospitalized in the Department of Neurology at the Affiliated Hospital of Yangzhou University from September 2023 to August 2024 were selected. Participants were those who underwent polysomnography (PSG) due to sleep-related complaints, such as daytime sleepiness, nocturnal snoring, insomnia, or frequent nighttime awakenings. The Montreal Cognitive Assessment (MoCA) was used to evaluate the cognitive function of patients. Participants were stratified into two groups based on MoCA scores (MoCA ≥ 26 and MoCA < 26) to investigate the differential effects of PLMS on cognitive function across distinct cognitive profiles. Multivariate linear regression models were used to evaluate the association between PLMS (periodic limb movement index, PLMI) and cognitive performance, adjusted for covariates including age, gender, education, smoking, total sleep time, and apnea-hypopnea index. Mediation analyses were performed to test whether REM sleep duration and PLMS-related arousal index (PLMAI) mediated the PLMS-cognition relationship. A total of 818 patients were included. Regression analysis showed that PLMI (β = - 0.033, 95% CI - 0.039 to - 0.026, p < 0.001) was negatively correlated with cognitive function. After adjusting for REM sleep duration and PLMAI, PLMI was still significantly associated with cognitive function (β = - 0.026, 95% CI - 0.034 to - 0.018, p < 0.001). PLMI was negatively correlated with REM sleep duration (β = - 0.157, 95% CI - 0.258 to - 0.056, p = 0.002) and positively correlated with PLMS-related arousal (β = 0.036, 95% CI 0.029-0.043, p < 0.001). The results of mediation analysis showed that REM sleep duration and PLMS-related arousal partially mediated the association between PLMS and cognitive function (indirect effect estimate = - 0.003, - 0.007; direct effect estimate = - 0.033). PLMS is associated with poorer cognitive function in middle-aged and elderly people, and REM sleep duration and PLMS-related arousal play a partial mediating role. Clinicians can utilize periodic limb movements during sleep (PLMS) as a potential early warning indicator of cognitive decline, enabling timely interventions to slow its progression. Additionally, improving REM sleep duration and suppressing PLMS-related arousals through pharmacological or non-pharmacological treatments may serve as critical strategies for preserving cognitive function.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».