The role of Life’s Crucial 9 in cardiovascular disease incidence and dynamic transitions to dementia
Notice bibliographique
Résumé
Cardiovascular disease (CVD) often coexists with dementia as the contributor to disease burden in the aging population. Although the effects of several modifiable factors on the CVD and dementia risk have been increasingly recognized, their impacts on their dynamic transitions have not yet been explored. Therefore, we aimed to explore the role of Life’s Crucial 9 (LC9; which includes measurements for diet, physical activity, smoking, BMI, cholesterol, blood pressure, blood sugar, sleep, and psychological health) in the dynamic transitions of CVD and dementia. Using the UK Biobank (351,945 CVD-free participants, aged 40–70, and 55.1% female), we applied Cox proportional hazard model and the multi-state model to explore the relationships of LC9 with the dynamic transitions of CVD to dementia. We further examined which component of LC9 (behavior subscale, biological subscale, and psychological health) contributed to these dynamic transitions. Of the total CVD-free participants, we find that there are 35,316 newly onset CVD cases and 5426 dementia cases with a maximum follow-up of 16 years. Findings reveal that higher LC9 scores are associated with a lower risk of CVD, dementia, and dynamic transitions from CVD to dementia. Furthermore, these results suggest that psychological health contributes more strongly to dynamic transitions from CVD to dementia than the behavioral or biological subscales (Atrial fibrillation to dementia: hazard ratio [HR] = 1.48, 95% confidence interval [CI] = 1.20–1.81; Ischemic stroke to dementia: HR = 1.39, 95% CI = 1.02–1.89; Myocardial infarction to dementia: HR = 1.48, 95% CI = 1.03–2.13; Heart failure to dementia: HR = 1.59, 95% CI = 1.22–2.07). Our findings highlight the need for closer surveillance of psychological health in CVD patients to lower the risk of subsequent dementia incidence. Zhang et al. explore the role of Life’s Crucial 9 (Life’s Essential 8 plus psychological health) in the dynamic transitions of cardiovascular disease (CVD) and dementia in the UK Biobank. The findings highlight the need for closer surveillance of psychological health in CVD patients to lower the risk of subsequent dementia incidence. Although the effects of lifestyle factors on the developing cardiovascular disease (CVD) and dementia have been increasingly recognized, their impacts on the dynamic transitions of CVD and dementia remains underexplored. Here, we studied the role of Life’s Crucial 9 (LC9; which includes measurements for diet, physical activity, smoking, BMI, cholesterol, blood pressure, blood sugar, sleep, and psychological health) in the transitions from CVD to dementia using a large UK database. We find that better LC9-defined cardiovascular health is associated with lower risks of dynamic transitions of CVD and dementia. We also find that psychological health contributes more strongly to all transitions from CVD to dementia. Our findings highlight the role of lifestyle behaviors, especially psychological health, in CVD patients to lower the risk of subsequent dementia incidence.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».