Association between educational attainment and amyloid deposition across the spectrum from normal cognition to dementia: A meta-analysis
Pourquoi ce travail est dans la base
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Notice bibliographique
Résumé
Background & Aim: Educational attainment has been proposed as a critical factor influencing cognitive resilience in the face of neurodegenerative diseases. However, its relationship with amyloid deposition across different stages of cognitive decline remains unclear. This systematic review and meta-analysis aimed to investigate the correlation between educational background and amyloid accumulation in individuals ranging from cognitively normal to those diagnosed with Alzheimer's disease (AD) or mild cognitive impairment (MCI). Methods: A comprehensive literature search was conducted in January 2025 across PubMed, Scopus, and Google Scholar to identify observational studies examining the association between educational attainment and amyloid deposition. Studies were included if they reported relevant data on this relationship; reviews, interventional studies, and those with insufficient outcome reporting were excluded. Data were analyzed using RStudio (version 4.3.1), employing random-effects or fixed-effects models based on the degree of heterogeneity. Effect sizes were expressed as Pearson's correlation coefficients (r). Results: Out of 6988 initially identified records, four cohort studies met the inclusion criteria, comprising a total of 288 participants from Canada and Japan. Meta-analysis revealed a significant positive correlation between educational attainment and amyloid deposition among individuals with MCI (r = 0.34, 95 % CI [0.05, 0.63]), although substantial heterogeneity was observed (I² = 86 %, p < 0.01). In contrast, an inverse association was found in patients with AD (r = -0.16, 95 % CI [-0.28, -0.03]), with minimal heterogeneity (I² = 0.0 %, p = 0.8101). Funnel plot analyses indicated no significant evidence of publication bias. Conclusion: These findings suggest a stage-dependent relationship between educational attainment and amyloid accumulation: higher education is associated with greater amyloid deposition in individuals with MCI, but with reduced amyloid burden in those with AD. This pattern supports the cognitive reserve hypothesis, which posits that education may bolster compensatory neural mechanisms, delaying the clinical onset of dementia symptoms. However, the presence of substantial heterogeneity and the limited sample size call for further longitudinal research to elucidate underlying causal pathways and inform targeted strategies for dementia prevention.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,001 |
| Bibliométrie | 0,000 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle