Association between HER-2 and Lymph Node Metastasis in Gastric Cancer: A Meta-Analysis
Notice bibliographique
Résumé
INTRODUCTION: Human epidermal growth factor receptor 2 (HER-2) in the development of gastric cancer has been widely discussed in the literature. This meta-analysis aimed to assess the relationship between HER-2 and lymph node metastasis in gastric cancer using systematic evaluation and meta-analysis, which can be of some clinical value for treatment and prognosis. METHODS: Relevant databases were searched according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. PubMed, Embase, Cochrane Library, and Web of Science databases were used to systematically search the literature published up to May 1, 2024. Twenty-one articles were screened and included for quantitative analysis, a data collection form was created, and the quality of the literature was evaluated using the Newcastle-Ottawa Scale (NOS). The results were represented by a Forest plot. I2 was used to assess heterogeneity, Begg's funnel plot was used to test for possible publication bias, and the source of heterogeneity was clarified by the Galbraith plot. Subgroup analyses were performed according to country and test method after excluding studies with significant heterogeneity. All statistical analyses were calculated using stata17.0. This study followed the PRISMA 2020 reporting specifications and the full checklist is available in the online supplementary material (online suppl. Table 4). RESULTS: A total of 624 articles were retrieved, and 21 were selected and included. Meta-analysis showed that there was heterogeneity between HER-2 positive and HER-2 negative mediators in the study (I2 = 68.0%, p < 0.000). Therefore, the 95% CI (3.12, 95% CI: 2.10, 4.65) of the combined OR calculated by the random-effects model was statistically significant. By comparing the incidence of lymph node metastasis between the HER-2 positive group and the HER-2 negative group, it was found that the incidence of lymph node metastasis between the two groups was significantly different. It is suggested that patients with HER-2 overexpression in cancer tissues may be more prone to lymph node metastasis. CONCLUSION: This meta-analysis showed an association between HER-2 and positive lymph node status in gastric cancer patients. This could be valuable for selecting treatment options for gastric cancer patients.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,007 | 0,002 |
| Bibliométrie | 0,002 | 0,003 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».