Abstract P4-01-08: PYNK at 20: From SABCS Inspiration to Multisite Clinical, Research, and Educational Program for Young Women with Breast Cancer
Notice bibliographique
Résumé
Abstract Introduction: The last session of the 2004 San Antonio Breast Cancer Symposium focused on the unique biological, fertility, and psychosocial issues faced by women diagnosed with breast cancer at age 40 or younger (YWBC). Attendees EW and JW, for whom this was a startling eye-opener, returned to Sunnybrook Health Sciences Centre in Toronto determined to create an interdisciplinary program for YWBC. Their vision was to ensure these patients received: 1) State-of-the-art clinical care, 2) A continuum of support for themselves and their families, and 3) Educational resources. Additional priorities would be: 4) Clinical and translational research focused on YWBC, and 5) YWBC-focused education of health care professionals. Today’s PYNK program - its origins and operations (including challenges and successes) - are described in this presentation. Methods: From January 2005 through January 2008 the program infrastructure was built. Steps included: Review of the literature on unmet needs of and existing programs for YWBC; Monthly meetings of a multidisciplinary executive from medical, radiation, and surgical oncology, nursing, social work, psychology plus 2 young breast cancer survivors; Presentations to skeptical colleagues and to ”management” who liked the concept but could not offer financial support; Establishment of a seamless fertility preservation referral process; Fundraising to pay a part-time nurse for the 1st year; Creation of a prospective research database, serial patient questionnaires, and a mechanism for storing baseline blood; and Selection of a name for the program: PYNK. Results: Since the enrollment of the first patient in Feb. 2008, there have been 40 to 50 newly diagnosed patients per year who remain in the program until discharged from our centre. Within 2 years a full-time nurse navigator became necessary. Since Jan. 2023 the navigator role has been taken over by a Physician Assistant (SV). Program objectives: 1 & 2) The navigator, along with the social worker (BM), meets the patient +/- accompanying family shortly after the 1st visit post-diagnosis, helps facilitate referrals/appointments, provides intensive support through active treatment, and medical/psychosocial support as needed thereafter. The navigator and social worker also co-lead 2 monthly support groups, one for non-metastatic and one for metastatic patients. A child life specialist is available when necessary for home visits to children. 3) In addition to brochures, books, and educational events, an online multimedia virtual library focusing on YWBC issues is maintained. 4) Consenting patients were enrolled in the prospective clinical database including family history, lifestyle factors, and serial psychological measures until 2015 when PYNK became one of the biggest contributors to the pan-Canadian RUBY (Reducing the bUrden of Breast cancer in Young women) prospective cohort. We have also enabled our patients to join pivotal trials such as the Dana Farber’s Young Women’s Breast Cancer Study and the Breast International Group’s POSITIVE study (NCT02308085). 5) Trainees of all levels and health disciplines rotate through PYNK clinics. In addition, we host formal CME events. Conclusions/Discussion: Since 2008, PYNK has helped hundreds of YWBC and their families manage their complex medical and psychosocial issues. PYNK research has resulted in numerous presentations and publications. Trainees learn unique skills and perspectives about YWBC management. In 2023 PYNK expanded to 2 additional donor-funded sites in the Greater Toronto Area. PYNK has not only been a model for other YWBC programs internationally but has sparked the creation of special programs for young patients in other disease sites. The greatest strength of PYNK has been the continuous input of the YWBC themselves on its executive. Citation Format: Sandy Vuong, Katarzyna Jerzak, Brooke Macdonald, Yonina Juni, Alexandra Landsberg, Karen Fergus, Judith Weinroth, Ellen Warner. PYNK at 20: From SABCS Inspiration to Multisite Clinical, Research, and Educational Program for Young Women with Breast Cancer [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P4-01-08.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,003 | 0,001 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,001 | 0,006 |
| Intégrité de la recherche | 0,001 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,222 | 0,044 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».