Abstract P2-03-01: Sexual health in unpartnered women after breast cancer: Report from a joint analysis of two international multi-site prospective cohorts of young breast cancer survivors
Notice bibliographique
Résumé
Abstract Objectives: Sexual dysfunction is a distressing potential side effect of breast cancer (BC) treatment. However, little is known about the experience of unpartnered young women whose concerns may differ from partnered peers. Helping Ourselves, Helping Others: The Young Women’s Breast Cancer Study (YWS-HOHO) investigates gaps in knowledge about young BC survivors in 2 multi-site prospective cohorts. Methods: The North American (USA, Canada) and European (Italy, Switzerland) YWS-HOHO cohorts jointly enrolled 1602 women. Participants were ≤40 yrs. and diagnosed with stage 0-IV BC <6 months before enrollment. Serial surveys were completed every 6 months for the first 3 yrs. and annually thereafter. Surveys included assessment of body image, sexual health, menopausal symptoms (using the CARES and BCPT scales, score range: 0-4, with higher scores indicating greater severity) and menopausal concerns. Unpartnered and partnered women were compared at baseline and 2-yrs. post-enrollment using T-tests. Results: A total of 1342 women were included in this analysis (1054 from N.A., 288 from Europe). The median age at enrollment was 37 yrs. (IQR 33-39), 81% of women had stage 0-2 disease. Most women (n = 1000, 74.5%) had received chemotherapy, 63.8% (n = 856) had undergone mastectomy. At baseline, 13% of women were unpartnered (n=180). Unpartnered young women reported significantly higher body image concerns than partnered peers at baseline (mean CARES body image scale 1.28 vs 1.09, p-value=0.04) but not at 2-yrs (1.17 vs 1.08, p-value=0.35). Concern about general sexual function was comparable for unpartnered and partnered women at baseline (1.97 vs 1.81, p-value=0.11) and at 2-yrs (1.43 vs 1.42, p-value=0.92). For example, >47% of both unpartnered and partnered women endorsed a loss of sexual interest at baseline and >36% of both groups also at 2-yrs. Unpartnered women reported fewer vaginal symptoms (e.g., vaginal dryness, pain with intercourse) than partnered women at both timepoints (mean BCPT vaginal scale at baseline 0.53 vs 0.83, p-value<0.001; at 2-yrs 0.74 vs 1.01, p-value=0.002), while there were no differences in hot flashes and urinary symptoms at either timepoint. Greater than 50% of both unpartnered and partnered women reported concern about becoming post-menopausal at both timepoints. Approximately half of unpartnered women reported difficulty with dating at both timepoints, including difficulty with initiating contact with potential partners and difficulty with discloser about their cancer experience. Conclusion and Implications: Unpartnered young BC survivors report similar levels of sexual dysfunction as partnered peers as well as distinct concerns about body image and dating. These findings underscore the need to routinely address sexual health regardless of partner status and to better investigate specific concerns of unpartnered women such as dating and relationship-building. Citation Format: Sharon Bober, Eleonora Pagan, Monica Ruggeri, Shari Gelber, Vincenzo Bagnardi, Ann Partridge, Olivia Pagani, Shoshana Rosenberg, Karin Ribi. Sexual health in unpartnered women after breast cancer: Report from a joint analysis of two international multi-site prospective cohorts of young breast cancer survivors [abstract]. In: Proceedings of the San Antonio Breast Cancer Symposium 2024; 2024 Dec 10-13; San Antonio, TX. Philadelphia (PA): AACR; Clin Cancer Res 2025;31(12 Suppl):Abstract nr P2-03-01.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».