Exploring the changes in functional connectivity of the limbic system in Patients with amnestic mild cognitive impairment treated by acupuncture based on fMRI
Notice bibliographique
Résumé
Objective: Brain functional connectivity (FC) of Limbic system plays an important role in maintaining the normal cognitive state. We conduct an investigation of the FC of limbic system networks in amnestic mild cognitive impairment (aMCI) and speculate on the brain effect mechanism of acupuncture therapy based on resting - state Functional Magnetic Resonance Imaging (rs - fMRI). Method: 50 patients with aMCI and 41 healthy participants (HC group) from the First Affiliated Hospital of Heilongjiang University of Chinese Medicine in Harbin City, Heilongjiang Province, China, were recruited.rs-fMRI data of all participants were collected. Among them, 35 aMCI participants (true-acupoint group) were treated with the Yuanluo Tongjing acupuncture method for two courses of treatment (once a day, needling every 10 min, retaining the needles for 40 min, 6 days of treatment + 1 day of rest, 4 weeks as one course, and starting the second course after an interval of 2 weeks). 15 aMCI participants (sham-acupoint group) received sham acupoint acupuncture intervention, and the specific intervention details were the same as those of the true-acupoint group. After treatment, rs-fMRI data of aMCI subjects were collected again. Thirty seed points of the limbic system were selected based on the Anatomical Automatic Labeling (AAL) template, and the Statistical Parametric Mapping (SPM) software was used for statistical analysis of FC indices between and within groups. Result: (1) Compared with the HC group, there were significant differences in the FC between Seed14 of the true-acupoint group before acupuncture intervention and multiple brain regions (enhanced with Seed 7 and weakened with Seed 15). There were differences in the FC of Seed4, Seed29, and Seed30 in the sham-acupoint group, indicating that there were baseline differences among aMCI patient groups. (2) After acupuncture in the true-acupoint group, the FC between multiple seed points and brain regions decreased, while the differences before and after the intervention in the sham-acupoint group mostly did not pass the Family-Wise Error (FEW) correction. (3) Compared with the HC group, the FC of seed points in both the true-acupoint group and the sham-acupoint group mainly decreased after acupuncture. The true-acupoint group involved a wider range of brain regions (the middle frontal gyrus, the left medial superior frontal gyrus, the middle part of the left cingulate gyrus and the gyri surrounding its lateral side, the gyri below the bilateral parietal bones except the supramarginal gyrus and the angular gyrus, the precuneus, etc.). (4) The FC between Seed14 and the left superior frontal gyrus medialis (Seed7), as well as the right caudate nucleus of the true-acupoint group was enhanced before acupuncture and decreased after acupuncture, which may serve as an observational indicators for the intervention of aMCI by acupuncture at acupoints. (5) The Montreal Cognitive Assessment (MoCA) score is more representative in characterizing the abnormal FC between brain regions in aMCI patients. Conclusion: The cerebral effect mechanism of acupuncture at acupoints for aMCI is more complex. It can regulate the functional connections within the limbic system and between the limbic system and other brain regions, mainly manifested as a decrease. Among them, the FC among Seed17-Parietal_Inf_L, Seed25-Frontal_Mid_L, and See25-Frontal_Sup_Medial_L has become a statistically significant detection index.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».