Sex and sex hormones determine myocardial infacrts size in a mouse model of sleep apnea
Notice bibliographique
Résumé
Introduction: Sleep apnea (SA) is associated with metabolic and cardiovascular diseases, such as diabetes and myocardial infarction (MI). Insulin resistance is a key metabolic alteration in diabetes that also aggravates MI. Intermittent hypoxia (IH - one of the main consequences of SA) induces insulin resistance and increases infarct size following myocardial ischemia-reperfusion (I/R) in rodents. However, while SA affects both sexes, most pre-clinical data have been obtained on males, limiting our understanding of sex-specific responses to IH and of the roles of sex hormones in males and females. Objective: We investigated whether sex and sex hormones determine myocardial infract size following IH and a potential association with insulin resistance. METHOD: C57Bl/6J mice underwent orchiectomy (ORX – males), ovariectomy (OVX – female) or sham surgery, followed by a 2-week recovery period. Mice were then exposed to 21 days of IH (21-5% O 2 , 60 episodes/hour, 8 hours/day) or normoxia (Nx). At the end of the IH or Nx exposures, after 6 hours of fasting, blood samples were collected (n=6 mice/groups) to measure insulinemia and glycemia and calculate the homeostatic model assessment of insulin resistance (HOMA-IR). Myocardial I/R injuries were induced on anesthetized mice (n=16/groups) by occlusion of the left coronary artery (45 minutes), followed by reperfusion (90 minutes) then injection of Evans blue. The hearts were dissected and later analyzed to determine the occluded and infarcted regions using colorimetric staining and planimetric measurement techniques. Results: In sham males, IH slightly (but not significantly) increases glucose and insulin levels, resulting in a significantly higher HOMA-IR, but these effects are not observed in ORX males. Additionally, while the occluded area is similar across groups, IH increases the infarcted area in sham males, but the opposite effect occurred in ORX males with a reduced infarcted area after IH vs Nx exposures. In sham females IH slightly reduces glucose levels, without altering insulin levels and the HOMA-IR, while it increases the infarcted area following myocardial I/R. In females maintained under normoxia, OVX slightly reduces glucose levels, but almost doubles insulin levels and the HOMA-IR, without altering the infarcted area following myocardial I/R. In OVX females, IH reduces insulin and HOMA-IR, but has no effect on the infarcted area. Conclusion: There is an apparent correlation between insulin resistance and the size of the infarcted area following IH only in males, thus the mechanisms underlying the elevated infarct size induced by IH could differ between males and females. Sex and sex hormones appear to be fundamental determinants of metabolic and cardiac responses to IH. Agir pour les maladies chroniques, Fédération Française de Cardiologie, CIHR. This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».