103 Moderate body weight loss and one-carbon metabolite supplementation in pregnant beef heifers during early gestation alters maternal and fetal morphometrics
Notice bibliographique
Résumé
Abstract The objective of this study was to determine if moderate changes in rate of body weight (BW) gain and dietary one-carbon metabolite (OCM) supplementation in pregnant heifers alters maternal and fetal morphometrics. In three experiments, Angus-cross heifers (n = 81) were stratified by BW into a 2 × 2 factorial arrangement of treatments: fed to gain 0.45 kg/d (CON) or lose 0.23 kg/d (RES) BW and to receive corn carrier with OCM supplement (+OCM) or without (-OCM). The OCM supplement consisted of vitamin B12 (20 mg/wk) and folate (320 mg/wk) injections and dietary rumen-protected methionine (7.4 g/d) and choline (44.4 g/d) from breeding (d 0) to d 63 of gestation. Heifers underwent estrus synchronization and were bred to a single sire via artificial insemination using female-sexed semen. In experiment 1, heifers (n = 31) were slaughtered on d 63 of gestation (early gestation). In experiment 2, heifers (n = 29) were slaughtered on d 160 of gestation (mid-gestation) and in experiment 3, heifers (n = 30) were slaughtered on d 250 of gestation (late gestation). Data were analyzed using the MIXED procedure of SAS to determine the effect of heifer gain, supplement, and their interaction. Statistical significance was considered at P ≤ 0.05. In all experiments, final BW, gain, and average daily gain were reduced (P < 0.01) in RES compared with CON heifers by experimental design. In experiment 1, maternal pancreas weight was reduced (P = 0.04) in CON-OCM, RES-OCM, and RES+OCM compared with CON+OCM. Fetal left cerebrum weight was reduced (P < 0.01) in CON+OCM and RES-OCM compared with RES+OCM, while CON-OCM was intermediate. Fetal right longissimus dorsi by brain weight was reduced (P = 0.03) in RES+OCM compared with CON+OCM, while CON-OCM and RES-OCM were intermediate. In experiment 2, there were no gain × supplement effects on maternal morphometrics. However, fetal mammary and fetal mammary by brain weight were reduced (P = 0.02) in CON+OCM compared with CON-OCM, while RES+OCM and RES-OCM were intermediate. In experiment 3, maternal kidney weight was reduced (P = 0.03) in CON+OCM and RES-OCM compared with CON-OCM, while RES+OCM was intermediate. Furthermore, empty uterine weight was reduced (P = 0.05) in CON+OCM and RES+OCM compared with CON-OCM, while RES-OCM was intermediate. There were no gain × supplement effects in fetal morphometrics. However, fetal mammary tissue adjusted by brain weight tended to be reduced (P = 0.08) in CON-OCM compared with CON+OCM, while RES+OCM and RES-OCM were intermediate. These data indicate our dietary restriction model was successful in causing moderate BW loss in pregnant heifers during early gestation. Furthermore, moderate BW loss in early gestation reduces maternal and fetal organ weights throughout gestation, and OCM supplementation did not substantially mitigate these effects.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».