P-467 Should we close the book of endometrial scratching?
Notice bibliographique
Résumé
Abstract Study question Does endometrial scratching improve pregnancy outcomes in patients with unexplained infertility undergoing intrauterine insemination? Summary answer Endometrial scratching might negatively impact pregnancy rate if done in luteal phase in IUI cycles. What is known already The role of Endometrial Scratching, also known, has been a debate for many years, with conflicting results. While some studies showed better implantation rates, others showed no benefit of endometrial injury on pregnancy outcome. It is believed that the inflammation caused by endometrial injury can lead to the release of growth factors and cytokines that may improve embryo implantation. Study design, size, duration This randomised controlled trial was conducted at the ovo clinic, a university-affiliated fertility center in Montreal, from May 2018 to March 2022. A total of 394 participants were recruited for the study and were randomized into the control group (n = 196) and the scratching group (n = 198) Participants/materials, setting, methods Couples with unexplained infertility and an indication for IUI were recruited. In the study group, endometrial scratching was performed during the follicular phase. All patients were followed for 3 consecutive months following randomisation. Ovarian stimulation was done for 5 days from day 2 or 3 of the cycle, and once the dominant follicle reached 18 mm and endometrial thickness reached at least 6.5 mm, HCG trigger was given and iui was done 36 hours later. Main results and the role of chance The live birth rate analysis of the post-insemination pregnancies over the 3 cycles following the ES, resulted in a risk ratio of 0.52 (95% CI: 0.30-0.92), indicating a significant reduction in live birth rates in the scratching group compared to the control group (p = 0.03) The compilation of results over the 3-month period shows that out of the 302 IUIs performed in the scratching group, 10.6% IUIs resulted in a pregnancy, compared to 12.4% in the control group (p = 0.54) Among these pregnancies, 40.6% resulted in miscarriages in the ES group, compared to 18.2% in the control group, the results were statistically significant(p = 0.04). Limitations, reasons for caution Main weakness of this study was that the causes of infertility were not correlated to the outcomes observed. Wider implications of the findings This study wold implicate that endometrial scratching should be aborted during intrauterine insemination cycles as it has negative effects on the outcomes. Trial registration number Yes
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».