Cardiac Stress in Intimate Partner Violence: The Role of Pain in Cardiovascular Disease Risk
Notice bibliographique
Résumé
Intimate partner violence (IPV) is a gendered epidemic disproportionately impacting women: two-thirds of victims identify as female. Globally, 35% of women report violence in a personal relationship with higher levels of unreported abuse. Cardiovascular disease is higher in females who experience IPV compared to males, although the mechanisms for these sex differences are unknown. Among the effects of IPV is chronic pain. Pain affects cardiac function and increases cardiovascular disease risk through similarly unknown mechanisms. We sought to determine how pain impacts the heart through sex-dependent pathways to explain sex differences in the connection between IPV and cardiovascular disease. Female and male C57Bl/6 mice (8-10 weeks old) were anesthetized and exposed to the spared nerve injury model of neuropathic pain, where the tibial and common peroneal branches of the sciatic nerve are severed and the sural branch is left intact. Mice recovered for 5 or 30 d and hearts were extracted for analysis. Cardiac myofilament activity was measured with a colourimetric assay for ATP consumption. Myofilament protein phosphorylation was assessed with ProD Diamond staining and collagen levels were quantified by spectrophotometry. Key elements of the RISK and SAFE signaling pathways were quantified by immunoblotting as markers of stress. Proteomic analysis was done by LC-MS/MS. Cardiac myofilaments had a significant increase in calcium sensitivity at 5 and 30 d in females, with no change in males. Phosphorylation of troponin T, tropomyosin, and myosin light chain 1 decreased in females by 30 d with only a transient decline in desmin and myosin light chain 1 phosphorylation in males at 5 d. STAT3, Akt, ERK1/2, and p70S6K had reduced activity in hearts from females at 5 and 30 d as indicated by decreased phosphorylation, while only ERK1/2 phosphorylation was decreased in males at 30 d. Proteomic analysis found 634 proteins whose expression or posttranslational modifications were altered at 5 or 30 d. Sex differences of >50% were detected in 400 proteins at 5 d and 490 at 30 d. These results reveal an increase in myofilament ATP consumption and a reduced baseline activity of the cardioprotective RISK and SAFE pathways in the hearts of female mice subjected to pain, but not males. Higher myofilament ATP consumption and reduced baseline activity of RISK and SAFE diminishes the ability of the heart to respond to stress, and could explain the increased risk of cardiovascular disease mortality in females who experience IPV. This work was supported with a National Women’s Health Research Initiative Catalyst grant from the Canadian Institutes of Health Research. This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».