Comparison of Ventilatory, Blood Oxygenation and Acid-Base Acclimatization Between Males and Females with Ascent to and Residence at 3500m over 10-days
Notice bibliographique
Résumé
With ascent to high altitude (HA), increased ventilation protects oxygenation but reduces the pressure of arterial (Pa)CO 2 (i.e., hypocapnia), resulting in respiratory alkalosis. Subsequent renal compensation is mediated through reductions in [HCO 3 - ]a, partly-correcting pHa. High inter-individual variability exists in ventilation, blood oxygenation, and acid-base responses with ascent to HA, but potential sex differences in ventilatory and renal acclimatization have not been characterized. We compared ventilatory, blood oxygenation and acid-base responses with rapid ascent to and residence at 3500m over 10-days between males and females. We recruited 38 lowland participants (18M; 20F) before and after rapid ascent to and residence at 3500m in La Paz, Bolivia, performing radial arterial blood draws (Abbott i-STAT) to assess blood oxygenation and acid-base variables before (1100m), and following ascent to 3500m both early HA (E-HA; days 2/3) and late HA (L-HA; days 9/10). Females had lower PaCO 2 and [HCO 3 - ]a at 1100m (P=0.0280, P=0.0119), confirmed with a larger archived dataset from our group (n=123; 71M, 52F; p<0.0001), suggesting higher basal ventilation and bicarbonate excretion in females at baseline, before ascent to HA. With E-HA, all participants had higher V· A , and lower PaO 2 and SaO 2 (p<0.0001), with subsequent increases in V· A , [Hb] and CaO 2 L-HA (P=0.0056; P=0.0003; P=0.0013). Although females had higher V· A and PaO 2 than males E-HA (p<0.0001; P=0.0143), males had higher [Hb] and CaO 2 at 1100m (p<0.0001), at both E-HA (P=0.0008; P=0.0085) and L-HA (P=0.0007; P=0.0045). E-HA, all participants had lower PaCO 2 and [HCO 3 - ]a, and higher pHa than 1100m (p<0.0001; P=0.0004, p<0.0001), suggesting respiratory alkalosis and partial renal compensation. L-HA, PaCO 2 and [HCO 3 - ]a were further reduced (P=0.0062; P=0.0202), with pHa only partly-compensated (P=0.4306). E-HA, PaCO 2 , [HCO 3 - ]a and pHa were significantly higher in males (p<0.0001; p<0.0001; P=0.0457), suggesting more complete renal compensation in females. However, these acid-base sex differences were not apparent L-HA (P>0.5341). Upon rapid ascent to and residence at 3500m, we demonstrated more rapid and larger magnitude ventilatory and renal responses in females. This is the first clear demonstration of differential ventilatory, oxygenation and acid-base compensation between sexes at baseline and with ascent to HA. Natural Science and Engineering Research Council of Canada, HBI RHISE and University of Calgary Transdisciplinary Connector Grants. This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».