Coastal marine fishes can combat ocean deoxygenation through respiratory plasticity
Notice bibliographique
Résumé
Climate change is increasing the occurrence and severity of marine hypoxia events worldwide. Hypoxia can impact marine fishes by constraining O 2 uptake and reducing the energy available for vital and non-vital functions. Here, we explored the hypothesis that the red drum ( Sciaenops ocellatus ) – an economically valuable species native to the coastal estuaries of the Gulf of Mexico – was capable of respiratory and metabolic plasticity that would mitigate the effects of hypoxia. Through a series of studies, we demonstrated that juvenile red drum exposed to hypoxia for up to 42 days exhibited significant plasticity that improved oxygen uptake affinity, tissue oxygen utilization efficiency and anaerobic capacity. Specifically, red blood cells exhibited dynamic transcriptional regulation of specific hemoglobin isoforms that correlated with reduced pH sensitivity and an overall increase in oxygen affinity. Furthermore, red muscle mitochondria exhibited improved OXPHOS control ratios and control efficiency, effectively allowing a greater amount of ATP to be generated per unit oxygen. These findings coincided with reduce hypoxia vulnerability (i.e. reduced critical oxygen thresholds) and higher maximum metabolic rates when tested in hypoxia, as well as a significant increase in anaerobic burst swimming capacity. Interestingly, there was no improvement in maximum metabolic rate when tested in normoxia. This is consistent with the notion that oxygen supply capacity reaches a plateau at higher oxygen tensions – a finding validated here for red drum by employing a hyperoxia exposure during maximum metabolic rate determination. Interestingly, embryonic red drum exposed to hypoxia during the first 72 hours post-fertilization and then reared to post-metamorphosis in normoxia also exhibited significant respiratory plasticity, but of an opposing nature. Contrary to expectations, hypoxia exposed embryonic fish showed compromised hypoxia vulnerability and elevated maximum metabolic rate when tested in normoxic environments, indicative of improved capacity for oxygen transport and utilization coincident with reduced respiratory system affinity. Overall, these data suggest that coastal marine species that commonly experience hypoxic events, such as red drum, have the capacity for respiratory plasticity that can mitigate the effects of hypoxia. However, the significance of this plasticity and how it can shape organismal outcomes can differ based on life stage. Funding for this work was provided by the National Science Foundation. This abstract was presented at the American Physiology Summit 2025 and is only available in HTML format. There is no downloadable file or PDF version. The Physiology editorial board was not involved in the peer review process.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
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