Neutrophil to-lymphocyte (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratios (PLR) as biomarkers for suicidal behavior in children and adolescents with depression or anxiety: A systematic review and meta-analysis
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Résumé
Introduction: Suicidal behaviour is a global phenomenon that has reached epidemic proportions due to the consistent rise in both completed and attempted suicides year after year, particularly among children and adolescents, who are the fifth leading cause of death in this demographic globally. Every year, over 700,000 individuals die by suicide, which equates to one death every 40 seconds on average. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) are blood markers of inflammatory status that are easy to use and reasonably priced. It was discovered that patients with depression or anxiety have higher NLR, MLR, and PLR. Thus far, there have been relatively few studies assessing biomarkers for the prognosis for suicidal behavior in children and adolescents with depression or anxiety and shown varying results. The aim of this meta-analysis is to assess NLR, MLR, PLR as predictive biomarkers for suicidal behavior in children and adolescents with depression or anxiety. Methods: A literature search was conducted through databases, such as PubMed, Cochrane, ScienceDirect, Ebsco, Springerlink to identify relevant topics up to March 2025. The inclusion criteria for this meta-analysis study were (1) studied patients with suicidal behavior in children and adolescents with depression or anxiety, (2) the study had to be a type of observational study that was reported the relationship between suicidal behavior in children and adolescents with depression or anxiety and NLR, MLR, PLR, (3) providing sufficient information about mean and standard deviation, (4) the publication language of studies is limited to English. The quality of research methods was assessed using a modified form of the Newcastle Ottawa Scale (NOS). The statistical analysis in this study was conducted using RevMan 5.4 software. Results: A total of 13 studies including 1192 depressed or anxiety patients with suicidal behavior and 1200 controls were included, with the majority of studies coming from Turkey. Our analysis revealed that depressed or anxiety patients with suicidal behavior had significantly higher NLR (SMD = 0.43, 95% CI: 0.15–0.72, p = 0.003), PLR (SMD = 11.31, 95% CI: 7.48-15.14, p < 0.00001), MLR (SMD = 0.02, 95% CI: 0.01-0.03, p < 0.00001) compared with controls. Risk bias assessment utilizing the NOS scale indicated that all studies showed good quality with minimal bias. Conclusion: Higher NLR, PLR, MLR were significantly associated with an increased risk of depressed or anxiety patients with suicidal behavior. Therefore further research is needed to develop this topic.
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,006 | 0,001 |
| Bibliométrie | 0,003 | 0,010 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle