Efficacy and Safety of Glucagon‐Like Peptide‐1 Agonists for Psychiatric Symptoms: A Systematic Review
Notice bibliographique
Résumé
BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as potential therapeutic options for psychiatric symptoms due to their effects on mood and behavior. However, their use has been primarily for metabolic diseases, and limited research has evaluated their psychiatric efficacy. This systematic review examined the impact of GLP-1 RAs on psychiatric symptoms, categorizing studies based on whether psychiatric outcomes were primary or secondary. METHODS: A comprehensive search through OVID databases from inception to November 2024 identified 26 studies (n = 3020), with 5 studies evaluating psychiatric symptoms as primary outcomes (e.g., substance use disorders) and 21 studies assessing secondary outcomes across various conditions. Additionally, 10 registered clinical trials were identified. RESULTS: Among the five studies targeting primary outcomes, exenatide and dulaglutide were investigated in cocaine use disorder, alcohol use disorder, and nicotine dependence. Exenatide 2 mg once-weekly demonstrated reductions in cocaine craving in two cases over 6 weeks in a case series study. However, mixed results were reported across studies, including no significant changes in a separate case series (n = 12, p = 0.46). Dulaglutide 1.5 mg weekly did not significantly affect smoking abstinence (RR = 0.87, p = 0.25) but reduced alcohol consumption by 29% in a secondary analysis. For studies assessing secondary outcomes, GLP-1 RAs showed variable effects. In mood disorders, liraglutide 1.8 mg/day significantly improved depression and anhedonia. In Type 2 diabetes, semaglutide improved diabetes-related quality of life (Cohen' and anxiety (Cohen's d = 0.48) compared to dulaglutide. Exenatide studies reported mixed results, with one randomized controlled trial (RCT) showing significant reductions in Beck's Depression Inventory (BDI) scores (Δ = -5.2). A total of nine RCTs were included in this review and the risk of bias was assessed using the JBI Critical Appraisal Checklist for RCTs. All included RCTs met the majority of criteria, indicating moderate-to-high methodological quality. Of the included RCTs, three reported a statistically significant effect on the primary psychiatric outcome, whereas six reported no significant effect. CONCLUSION: GLP-1 RAs showed mixed and inconclusive effects on psychiatric symptoms. Although some studies suggested potential benefits, others reported null findings. Given the variability across trials, further research is needed to clarify their therapeutic potential.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,003 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».