Effect of Tirofiban on Cognitive Function in Patients With Unruptured Intracranial Aneurysms After Endovascular Embolization
Notice bibliographique
Résumé
Aims/Background An unruptured intracranial aneurysm (UIA) is a cerebrovascular disease with a potential risk of rupture. Rupture of UIA is a leading cause of spontaneous subarachnoid hemorrhage, which carries a high mortality rate. While endovascular intervention emerged as the primary treatment option for UIA, postoperative cognitive dysfunction (POCD) remains a common complication, affecting patients’ postoperative recovery. Therefore, identifying effective interventions is clinically crucial for improving postoperative cognitive function. Tirofiban, an antiplatelet agent, has shown potential neuroprotective effects in neurointerventional procedures. Hence, this study aims to evaluate the effect of tirofiban on postoperative cognitive function in patients with UIA. Methods This retrospective study analyzed 125 UIA patients who underwent treatment between January 2021 and December 2024. All patients underwent simple coil embolization and were divided into two groups: an observation group (treated with tirofiban) and a control group (without tirofiban). Before surgery, these patients were routinely treated with aspirin and clopidogrel. However, patients in the observation group were given tirofiban in addition to standard care for 12 hours after the procedure. Furthermore, cognitive function was assessed before and after surgery using the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores. Additionally, the incidence of postoperative silent cerebral infarction (SCI) and variations in inflammatory marker levels were compared between the two groups. Results Cognitive function showed no significant difference between the two groups before surgery. After the procedure, the observation group demonstrated significantly higher MoCA (p < 0.001) and MMSE (p = 0.001) scores than the control group, indicating a significant advantage of tirofiban in improving cognitive function. Within 72 hours postoperatively, 7 cases in the observation group developed SCI compared to 18 cases in the control group, with a significantly lower incidence of SCI in the observation group (p = 0.025). Preoperative comparison of inflammatory markers revealed no difference between the two groups (p > 0.05). However, their postoperative levels were significantly lower in the observation group (p < 0.05). The cognitive function scores remained significantly higher in the observation group than in the control group over one month follow-up period (p < 0.05). Conclusion Tirofiban improves cognitive function and reduces SCI and inflammation following UIA embolization, possibly via antiplatelet and anti-inflammatory mechanisms. While statistically significant, the clinical relevance of cognitive improvement (1 point) is limited and requires further investigation. Furthermore, prospective randomized trials are needed to validate the long-term efficacy of tirofiban and elucidate underlying mechanisms.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».