Associations between the gut microbiota at one-year and neurodevelopment in children from the SEPAGES cohort
Pourquoi ce travail est dans la base
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Notice bibliographique
Résumé
Fundamental research indicates a communication between the gut microbiota and the central nervous system, referred to as the microbiota-gut-brain axis. This link is little characterized in humans in the general population. We prospectively investigated the relationships between the gut microbiota composition of one-year-old children and neurodevelopment parameters at 2 and 3 years of age. Within the SEPAGES French couple-child cohort, we profiled gut microbiota by sequencing the V3-V4 region of the 16S rRNA gene from stool samples in 356 children at 12 months of age. We later assessed children's neurodevelopment through validated tests (CBCL at 2 years, and SRS-2, BRIEF-P and WPPSI-IV at 3 years). Microbial α-diversity indices, the 4 most abundant phyla, and the 46 most abundant genera were analyzed for their relations with neurodevelopmental parameters using multiple linear regression, while associations of β-diversity with neurodevelopment were examined through PERMANOVA tests. α- and β-diversity indices were not associated with neurodevelopmental parameters in children. Suggestive associations were observed with taxonomy, but not maintained after correction for multiple comparisons: phyla Proteobacteria and Bacteroidetes tended to be associated with higher socio-emotional neurodevelopment assessed with different sub-scores; phylum Firmicutes with increased plan and organization problems; genera Lactococcus , Coprococcus, Oscillibacter, Clostridium XVIII , Veillonella, Parabacteroides, Subdoligranulum and Saccharibacteria genera incertae sedis with lower socio-emotional neurodevelopment, while genera Enterococcus and Butyricicoccus tended to be associated with higher socio-emotional neurodevelopment, assessed with different sub-scores. Within this generally healthy population, only suggestive associations were observed between gut microbiota composition and neurodevelopmental scores at 2 and 3 years. Larger studies are needed to examine a possibly weak link between the gut microbiota of one-year-old children and their neurodevelopment. • We investigated the link between infant gut microbiota and neurodevelopmental scores. • α- and β-diversity indices were not associated with neurodevelopmental scores. • Suggestive associations of gut microbiota with neurodevelopmental scores were seen. • These associations were not maintained after correction for multiple comparisons. • Larger prospective studies are needed to examine a possibly weak link.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle