SCORE: Serologic evidence of COVID-19 and social and occupational contacts in healthcare workers in long-term care and acute care facilities in Southeastern Ontario (SCORE)
Notice bibliographique
Résumé
INTRODUCTION: We established a longitudinal cohort of healthcare workers (HCWs) in an acute care hospital (ACH) and four long-term care homes (LTCHs) in Ontario, Canada, to follow the incidence of SARS-CoV-2 infection, humoral immune response to infection and/or vaccination, and determinants of infection risk. Here, we 1) describe the cohort regarding the distribution of main exposures, outcomes and serologic assays, 2) describe the unadjusted incidence of SARS-CoV-2 infection risk in the overall population, and 3) summarize the analysis and its pertinence. METHODS AND PARTICIPANTS: HCWs were recruited between November 24, 2020, and July 24, 2021. They completed a baseline survey, monthly surveillance for 9-12 months, a post-Omicron-wave survey, and provided blood samples for anti-SARS-CoV-2 antibody measurements. We collected data on host-related (humoral response to vaccines and SARS-CoV-2 infection) and environmental factors (social contact history and occupational, household and community conditions). Descriptive analysis by setting, comparison of distributions, and unadjusted survival analysis were performed. RESULTS: In total, 143 HCWs from the ACH and 57 from LTCHs had complete data, and 72% were followed until September 2022. Nearly 60% of the sample consisted of nurses, nurse assistants and personal support workers. Survival analysis showed that the risk of infection was bimodal, with low risk throughout the study period until the first Omicron wave. ACH HCWs had a higher risk of infection during the Omicron waves than during the preceding waves (Odds Ratio = 7.64; CI95%: 4.24-13.7), while LTCH HCWs at high-risk facilities experienced a similar risk of infection before and during the Omicron waves (OR = 1.76; CI95%: 0.63-4.9). During the Omicron waves, the use of protective equipment by HCWs working with institutional COVID-19 cases increased, but the use of community protective measures diminished. Household infections reported by participating HCWs also increased during the Omicron waves compared to previous waves. Immunoglobulin G (IgG) antibody levels increased over two time periods, (Pre vs Post- Omicron) likely due to the immune response to high levels of both vaccination and SARS-CoV-2 infections. DISCUSSION: We observed a low incidence of COVID-19 until the onset of the Omicron waves, which highlights the drastic impact of this Variants of Concern (VOC) on transmission and the importance of infectious agent characteristics. Our analysis indicated a ninefold increased risk of infection compared to that in earlier pandemic periods. Further analysis will allow the estimation of 1) the risk factors for SARS-CoV-2 infection at the community, household and healthcare facility levels, 2) the relationship between humoral responses and SARS-CoV-2 infection/vaccination, and 3) the role of social contact in work, household and community settings in the risk of infection.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».