Correlation analysis of cognitive dysfunction and fluctuations in serum fibroblast growth factor 21 (FGF21) levels in the overweight group
Notice bibliographique
Résumé
Background: To explore the changing characteristics of cognitive function in overweight/obese (OWO) adolescents and analyse its relationship with the level of serum fibrob-last growth factor 21 (FGF21). Methods: A total of 175 adolescents were selected and divided into a normal body mass index (BMI) group (n = 50), an overweight BMI group (n = 50), and an obese BMI group (n=75). All participants underwent assessment of anthro-pometric indicators (height, weight, waist circumference, BMI Z score). Fasting venous blood was collected to meas-ure the level of serum FGF21 (by enzyme-linked immuno-sorbent assay (ELISA)), as were metabolic parameters such as fasting plasma glucose (FPG), fasting insulin (FINS), gly-cated haemoglobin (HbA1c), and lipid profiles (TC, TG, LDL-C, HDL-C). Overall cognitive function was evaluated via the Chinese version of the Montreal Cognitive Assess-ment Foundation Scale (MoCA-B), executive function was assessed via the Wisconsin Card Sorting Test (WCST) (with a focus on analysing the number of persistent errors/PE and the number of completed classifications/CC), and working memory was evaluated via the number span test (DST). Independent sample t tests or Mann Whitney U tests were used to compare the differences between groups. Pearson or Spearman correlation analysis was used to explore the relationships between serum FGF21 levels and cognitive indicators and metabolic parameters. Multiple linear regres-sion was used to analyse the independent association between serum FGF21 and cognitive function scores (after adjusting for potential confounding factors such as age, sex, BMI Z score, and HOMA-IR). Results: Compared with those of normal individuals, the sys-to-lic blood pressure, diastolic blood pressure, fasting blood glucose, glycated haemoglobin and triglyceride levels of ado-lescents in the obese group were greater (all P<0.05). Under the consistent or inconsistent stimulation conditions of the Flanker task, there was no statistically significant differ-ence in the ACC between any two groups of adolescents. Compared with those in the normal body type group and the overweight group, the reaction time of adolescents in the obese group was prolonged (all P<0.05). In the n-back task, there was no statistically significant difference in the ACC between any two groups of adolescents. However, the response time of adolescents in the obese group in the 1-back and 2-back tasks was longer than that in the normal body type group and the overweight group (all P<0.05). Compared with those in the normal body type group, the serum FGF21 levels of adolescents in the obese group were greater (P=0.001). The results of the partial correlation analysis revealed that the reaction time of adolescents in the Flanker and n-back tasks was correlated with their BMI, body fat mass, waist circumference, waist hip ratio, FGF21 level, etc. (all P<0.05). Multiple linear regression analysis further confirmed that BMI was associated with prolonged response time in cognitively related behavioural tasks in adolescents (all P<0.05), and the level of FGF21 was correlated with the ACC in the 2-back task (P=0.001) and the response time to inconsistent stimuli (P=0.048). Conclusions: Overweight adolescents have significant cogni-tive impairment, with significantly elevated serum FGF21 lev-els, and elevated FGF21 levels are independently associated with poorer overall cognitive and executive functions.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».