The associations of suicidal ideation with psychopathology and inflammatory cytokines in patients with chronic schizophrenia
Notice bibliographique
Résumé
BACKGROUND: Suicidal ideation (SI) is common in patients with chronic schizophrenia, but the exact mechanisms underlying its development are unclear. Therefore, this study aimed to initially assess the prevalence of SI and to thoroughly explore the potential associations between SI and general demographic factors, psychopathological characteristics, and inflammatory cytokines in patients with chronic schizophrenia. METHODS: From May to December 2018, 302 patients with chronic schizophrenia were included in this study. A self-administered questionnaire was used to collect general demographic data, and a series of scales were used to assess SI, psychotic symptoms, depression, insomnia, involuntary movements, extrapyramidal side effects, and akathisia symptoms, respectively. Additionally, plasma levels of inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-17 A and tumor necrosis factor-α (TNF-α) were measured. By logarithmic transformation with a base of 10, the values of Log IL-1β, Log IL-6, Log IL-17 A, and Log TNF-α were yielded. Among these, SI was designated as the dependent variable, with other psychopathological symptoms and inflammatory cytokines serving as independent variables, while general demographic factors were controlled for as potential confounders. Finally, multifactorial logistic stepwise regression analyses were performed to identify independent factors influencing SI in patients with chronic schizophrenia. Receiver operating characteristic (ROC) curve analyses were then used to assess the predictive value of each identified independent factor for SI. RESULTS: The prevalence of SI (lifetime) and SI (last week) in patients with chronic schizophrenia was 36.4% and 8.0%, respectively. After controlling for general demographic factors such as age, Body Mass Index (BMI), and years of education, regression analyses showed that being female, Calgary Depression Scale (CDSS) score and Log IL-1β were independent correlates of patients' SI (lifetime), while chlorpromazine equivalents, Positive and Negative Syndrome Scale (PANSS) score, CDSS score and Log IL-6 were independent correlates of SI (last week). Additionally, ROC curve analyses showed that the combination of both CDSS score and Log IL-1β items demonstrated better discriminative ability of SI (lifetime). And the four-item combination of chlorpromazine equivalents, PANSS score, CDSS score and Log IL-6 was a better predictor of SI (last week). CONCLUSION: There was higher overall risk of SI in patients with chronic schizophrenia. SI might be associated with psychotic symptoms, depression, insomnia, medication side effects, and increased levels of inflammatory cytokines. In clinical practice, doctors should take prompt preventive measures in patients combining suicidal risk factors.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».