Hemodynamic Assessment of Arterial Perfusion by Using the Ultrasonographic Hand Acceleration Time: Protocol for a Cross-Sectional Prospective Descriptive Study
Notice bibliographique
Résumé
BACKGROUND: Several noninvasive methods can be used to assess hand perfusion, but none have been standardized for diagnosing chronic upper limb ischemia. One potentially useful diagnostic tool for this purpose is the ultrasonographic hand acceleration time (HAT), although it still requires characterization and validation. OBJECTIVE: This study aims to describe the technique for assessing hand perfusion through HAT while quantifying it in patients with chronic upper limb ischemia and healthy volunteers. METHODS: This prospective, cross-sectional, and descriptive study evaluates HAT measurements by using vascular duplex ultrasound (DUS), a novel technique for assessing hand arterial perfusion. This study includes adult patients with chronic upper limb ischemia and healthy volunteers without cardiovascular risk factors. HAT was measured in 4 different hand arteries. A standard descriptive analysis was performed, along with comparisons using the Mann-Whitney U test, when applicable. This study received institutional review board approval, and no study-related procedures were performed prior to signing the written informed consent. This research complied with the Declaration of Helsinki, Good Clinical Practice guidelines, and Spanish regulatory requirements. RESULTS: As of June 2023, 30 participants were enrolled in the study, comprising 15 patients and 15 healthy volunteers, resulting in a total of 15 ischemic and 30 nonischemic hands. Data analyses were concluded in late November 2023, and results were sent for publication in February 2024. The manuscript containing the results was accepted in May 2024 and published online in July 2024, becoming available in PubMed in December 2024. The results have already been made available to the scientific community prior to the submission of this protocol. This study protocol was submitted for publication in July 2024 to enhance transparency and to offer comprehensive methodological insight into the HAT technique. No additional analyses beyond those reported in the published study are planned. CONCLUSIONS: This study presents the first systematic evaluation of HAT measurements by using vascular DUS as a novel diagnostic tool for chronic upper limb ischemia. By comparing ischemic and nonischemic hands, this study aims to establish preliminary cutoff values that may aid clinical decision-making. Although prior studies have only reported HAT measurements in case reports, this study provides quantitative data on its feasibility and potential clinical application. Despite its small sample size, which limits subgroup analysis and generalizability, the study serves as a foundation for future research by providing essential data for refining cutoff values and informing sample size calculations for larger studies. Although examiner dependence could introduce systematic bias, the standardized methodology ensures consistency across all measurements. Ultimately, HAT may emerge as a quick, noninvasive diagnostic tool for chronic upper limb ischemia, potentially complementing existing nonstandardized methods such as the digital-brachial index, digital pressures, and plethysmography. TRIAL REGISTRATION: ClinicalTrials.gov NCT05977725; https://clinicaltrials.gov/study/NCT05977725. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): RR1-10.2196/64450.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,017 | 0,010 |
| Méta-épidémiologie (sens strict) | 0,003 | 0,001 |
| Méta-épidémiologie (sens large) | 0,003 | 0,001 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,002 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,021 | 0,007 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».