Adolescent Dietary Intake and Breast Cancer in Adulthood: A Systematic Review and Meta-analysis
Notice bibliographique
Résumé
: Adolescence represents a key opportunity for breast cancer prevention, as the rapid proliferation of breast tissue during puberty creates a critical window of vulnerability for the development of cancerous cells. With increasing research on adolescent dietary factors and breast cancer risk, we conducted a systematic review and meta-analysis to summarize the associations between adolescent diet and risk of breast cancer in adulthood, as well as benign breast disease (BBD) and high mammographic breast density, which are markers for breast cancer. We searched Web of Science, Ovid MEDLINE, Cochrane CENTRAL and Embase for epidemiological studies assessing dietary intakes in adolescent girls (aged 10-18 years), published through 16 October 2024, with no language or time restrictions. Study quality was assessed using the Newcastle-Ottawa Scale and results were pooled using random-effects models. The review included 51 studies, mostly from the USA, with the majority relying on adult recall of adolescent diet, and only 20 studies assessed as high quality. Higher adolescent intakes of fruits and vegetables (RR: 0.90; 95% CI: 0.82, 0.99; n=3 studies), soy (RR: 0.67; 95% CI: 0.55, 0.82; n=3), dietary fiber (RR: 0.78; 95% CI: 0.67, 0.92; n=3), and vegetable fat (RR: 0.76; 95% CI: 0.66, 0.88; n=2) were associated with lower risks of breast cancer in adulthood. No significant associations were observed for meat and poultry, fish, processed meat/fish, eggs, dairy, milk, grains, alcohol, total fat, animal fat, and isoflavone. Additionally, greater consumption of dietary fiber (RR: 0.64; 95% CI: 0.50, 0.82; n=2) and vitamin D (RR: 0.77; 95% CI: 0.62, 0.95; n=2) during adolescence was associated with lower risks of BBD, while no dietary associations were observed for mammographic breast density. Our findings underscore the importance of both diet and timing in breast cancer prevention. Future well-designed prospective life course studies are needed to strengthen this evidence base. Registry This systematic review and meta-analysis was registered with PROSPERO (CRD42024532597). Statement of significance To our knowledge, this is the first comprehensive review to review and quantify the association between adolescent intake of various dietary components and breast cancer risk in adulthood. Current dietary strategies for breast cancer prevention are largely informed by epidemiological evidence from studies involving adult populations. Our findings offer preliminary insights into potential pathways linking dietary exposures during adolescence to breast cancer development. We also identify critical gaps in adolescent research, emphasizing the need for continued high-quality research targeting the formative years to inform future prevention efforts.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,007 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».