Fine particulate matter exposure and sperm DNA fragmentation in US men: a spatial cross-sectional study
Notice bibliographique
Résumé
STUDY QUESTION: Does exposure to fine particulate matter (PM2.5) impact sperm DNA fragmentation? SUMMARY ANSWER: Higher PM2.5 exposure was associated with increased sperm DNA fragmentation, with greater effects observed in men of lower socioeconomic status (SES). WHAT IS KNOWN ALREADY: Environmental air pollutants such as PM2.5 have been linked to adverse reproductive and perinatal outcomes. However, their impact on sperm chromatin integrity remains underexplored, particularly in the context of geographic and sociodemographic modifiers. STUDY DESIGN, SIZE, DURATION: This was a cross-sectional study including 21 851 semen samples collected between 2005 and 2022 from men undergoing fertility evaluation across multiple US regions. PARTICIPANTS/MATERIALS, SETTING, METHODS: Semen samples were obtained from men older than 18 years, with testing performed in a single reference laboratory. Exposure to PM2.5 was estimated using validated satellite-derived models and aligned with the 70-80 day spermatogenic window prior to sample collection. Spatial linear mixed-effects models incorporating natural splines and geographic correlation structures were used to assess nonlinear associations between PM2.5 and sperm DNA fragmentation index (DFI), while adjusting for age, SES, population density, and racial composition. Interaction terms were used to evaluate effect modification. MAIN RESULTS AND THE ROLE OF CHANCE: Higher PM2.5 exposure was associated with increased DFI (estimate = 0.45; P = 0.0025), with a clear nonlinear dose-response pattern peaking at ∼11 µg/m³. A significant interaction was observed between PM2.5 and SES (estimate = 0.45; P = 0.0148), indicating that men from lower SES areas experienced stronger pollution-related DNA damage. Age remained a strong independent predictor: men ≥50 years showed markedly elevated DFI (estimate = 14.36; P < 0.0001). LIMITATIONS, REASONS FOR CAUTION: The sample was derived from men seeking fertility evaluation and may not represent the general population. ZIP-code level SES and exposure proxies may not reflect to the full extent an individual-level exposures, and residual confounding is possible. WIDER IMPLICATIONS OF THE FINDINGS: These results underscore the reproductive health consequences of environmental air pollution and its intersection with social inequality. PM2.5 exposure may disproportionately affect sperm chromatin quality in disadvantaged populations; this finding supports targeted environmental and reproductive health interventions. Sperm DNA fragmentation may serve as a biomarker of environmental and social stress. STUDY FUNDING/COMPETING INTEREST(S): This study was internally funded. V.X.D. and B.M. are employees of ReproSource, which provided laboratory testing, and Quest Diagnostics. No other conflicts of interest were reported. TRIAL REGISTRATION NUMBER: N/A.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».