Paternal Influences on Offspring Bone, Muscle and Growth in Childhood and Adulthood: A Systematic Review
Notice bibliographique
Résumé
ABSTRACT Objective There is a growing body of evidence examining the paternal origins of health and disease. This review aimed to systematically search extant literature regarding the relationship between paternal lifestyle and health exposures during early life, conception or pregnancy and offspring childhood and adulthood musculoskeletal, body composition and growth measures. Data Sources The MEDLINE, Embase, CINAHL and Cochrane Library electronic databases were searched using both subject headings and free‐text terms for the fathers’ exposures and offspring outcomes. All published literature in the English language from each database's inception through to October 2024 was queried. Forward and backwards citation screening of all relevant articles was conducted. Study Eligibility Criteria Experimental and observational studies assessing any paternal exposure during early life, peri/conception or pregnancy, and their association with offspring growth and musculoskeletal health measures in infancy, childhood and adulthood were included. For the purpose of this paper, only papers featuring offspring measures in childhood and adulthood have been discussed. Study Appraisal and Synthesis Methods The extracted data were primarily descriptive and included information on the study design, sample size, paternal exposure, offspring outcome, timeframe of offspring outcome measurement, major findings and the confounding variables included in statistical models. Risk of bias was assessed using the Newcastle–Ottawa tool. The studies were characterised based on the outcome assessed. This study was registered with the International Prospective Register of Systematic Reviews. Results In total, 290 papers met the inclusion criteria of the review, of which 118 reported on offspring outcomes during childhood and adulthood. Some paternal exposures appear to have an association with musculoskeletal and growth measures in offspring during childhood and adulthood. However, there is limited evidence and contradictory findings for many reported paternal exposures. Conclusions This systematic review indicates that some paternal exposures, such as body mass index and smoking, appear to have an association with offspring childhood and adulthood musculoskeletal and growth measures. Further research is required to determine if there are associations with other paternal exposures and whether the reported associations hold true in larger, more robust studies.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».