Perceptions of Long-Acting Injectable Pre-Exposure Prophylaxis Among Men Who Have Sex With Men and Transgender Individuals in Europe Using Structural Text Modeling Technique: Cross-Sectional Study
Notice bibliographique
Résumé
BACKGROUND: Oral pre-exposure prophylaxis (PrEP) effectively prevents HIV but remains unevenly accessible across Europe. Long-acting PrEP (LA-PrEP), recently approved in Europe, offers new HIV protection options. However, no qualitative evidence is available to inform people's perceptions of this novel modality. OBJECTIVE: This study provides the first large-scale, qualitative evidence in English from 20 European countries on how men who have sex with men (MSM) and trans* individuals perceive LA-PrEP. METHODS: We analyzed open-ended responses from 3123 HIV-negative MSM and trans* individuals from 20 European countries who completed the PROTECT survey in English. Participants were asked to describe what LA-PrEP means to them using words or short phrases. We used word clouds for initial insights and structural topic modeling to identify topics and explore their relevance across socioeconomic status, migration background, oral PrEP use, and affordability and the association of these perceptions with LA-PrEP intention. RESULTS: The responses reflected generally positive associations toward LA-PrEP, with the most frequently mentioned word being "safe," "freedom," and "convenient." However, some ambivalent and negative perceptions, such as "nothing," "unknown," "dunno," and "unnecessary," were also noted. Structural topic modeling identified 5 main response topics: safety, empowerment, convenience/reliability, peace of mind, and concerns/uncertainties. The empowerment offered by LA-PrEP was the most prominent topic, representing one third (28.1%) of the responses, followed by safety (21%), convenience and reliability (16%), and peace of mind (15%), while concerns/uncertainties made up 20%. Variation in the relevance of these topics was found, showing LA-PrEP being seen as more empowering (=.070, 95% CI 0.042-0.097) and convenient (=.057, 95% CI 0.034-0.081) by current oral PrEP users, but less empowering (=-.052, 95% CI -0.087 to 0.017) and convenient (=-.034, 95% CI -0.064 to 0.005) for individuals in countries with limited oral PrEP access and affordability. The topic of safety was more relevant among those with lower levels of education (=.052, 95% CI 0.022-0.083) and those living in a country where PrEP was not reimbursed (=.035, 95% CI 0.002-0.069), but less relevant among current oral PrEP users (=-.094, 95% CI -0.12 to 0.066). We also found that ambivalent and negative perceptions were less relevant among current oral PrEP users (=-.032, 95% CI -0.056 to 0.007) and were negatively associated with a lower intention to use LA-PrEP (=-.075, 95% CI -0.101 to 0.005). CONCLUSIONS: Our research showed that MSM and trans* individuals in Europe generally have a positive outlook on LA-PrEP, suggesting it is likely to be well accepted upon its introduction in Europe. However, a subset of the target population may be hesitant to adopt LA-PrEP, underscoring the need for alternative HIV prevention strategies tailored to these individuals. To support potential future LA-PrEP implementation in Europe and to maximize its impact, appropriate communication strategies are essential for supporting informed decision-making.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,009 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».