Effects Of Exercise Training On Body Composition And Sarcopenia In People With Advanced Lung Cancer
Notice bibliographique
Résumé
Sarcopenia is characterized by progressive skeletal muscle loss and has been associated with increased morbidity and mortality in patients with advanced lung cancer. Exercise interventions have demonstrated significant clinical benefits for patients with advanced cancer. PURPOSE: This study assessed the effect of a virtual exercise intervention for patients with advanced lung cancer on body composition, including skeletal muscle mass. METHODS: 27 participants with advanced lung cancer (median age = 66 years) undergoing systemic therapy in British Columbia, Canada participated in a 12-week supervised group exercise program delivered twice a week via Zoom. The 30-second sit-to-stand (30s STS) and 8-foot timed up and go (TUG) test were assessed at baseline and post-intervention. Changes in body composition were measured using pre- and post-intervention abdominal computed tomography (CT) scans. Height-adjusted muscle quantity was measured as skeletal muscle index (SMI), and muscle quality was measured as skeletal muscle density (SMD) and skeletal muscle gauge (SMG), which is SMI multiplied by SMD. Quantities of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and intermuscular adipose tissue (IMAT) were also measured. CT-derived sarcopenia was defined using body mass index (BMI) and sex-specific SMI cutoff points. Performance-derived sarcopenia was defined using sex-specific TUG and 30s STS cutoff points. Finally, combination-derived sarcopenia was defined using sex-specific cutoff points of the 30s STS, SMI, and SMD. Paired t-tests were used to assess pre- and post-intervention changes in body composition scores. RESULTS: SMI increased from 43.1cm2/m2 to 44.0cm2/m2 (p = 0.033). There were no significant changes in SMD, SMG, SAT, VAT, or IMAT. The percentage of participants that met the criteria for sarcopenia decreased from 73% at baseline to 64% post-intervention for CT-derived sarcopenia, 91% to 82% for physical performance-derived sarcopenia, and remained constant at 82% for combination-derived sarcopenia. CONCLUSION: A 12-week virtually supervised exercise program for patients with advanced lung cancer improved the quantity of skeletal muscle and decreased the proportion of participants categorized as sarcopenic, using body composition and physical performance. Supported by: This work was supported by BC Lung [UBC Number F21-00722] and the BC Cancer Foundation (UBC Number F23-05978). R. A. Fujita was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES PrInt, grant 30/2022, process #88887.695669/ 2022-00).
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,002 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».