A-266 Comparative Evaluation of Bacteriostatic Efficacy in Preserved Room-Temperature vs. Unpreserved Refrigerated Urine Containers
Notice bibliographique
Résumé
Abstract Background Urinary tract infections (UTIs) are common bacterial infections, diagnosed through urine culture, which typically requires refrigerated storage to prevent bacterial overgrowth. Alternatively, collection and preservative devices such as the novel UriSponge (Copan Diagnostics, Murrieta, California) are used to maintain specimen integrity. This study evaluates the bacteriostatic efficacy of the newly reformulated UriSponge in preserving urine samples at room-temperature and during delayed processing conditions. No studies currently exist that demonstrate its effectiveness in a clinical setting. Methods Midstream urine samples were collected and aliquoted at a clinic, then transported to the testing laboratory to facilitate assessment of refrigerated and UriSponge-preserved conditions. Aliquots were stored refrigerated (unpreserved) and at room temperature (UriSponge-preserved) until plating. Samples were plated on Brilliance UTI Clarity agar (ThermoFisher Scientific, Waltham, MA) at ∼11 and ∼34 hours post-collection. A total of 451 specimens were assessed using WASPLab and PhenoMATRIX. Cultures were reviewed for agreement across different sample storage conditions. Results UriSponge-stored aliquots demonstrated strong agreement with unpreserved urine aliquots. Categorical interpretations of no growth (NG), non-significant growth (NSG), significant growth (SG), and mixed growth (MG) were assigned. Categories of NG, NSG, and MG were considered clinically insignificant while SG was considered clinically significant. Aliquots plated ∼11 hours post-collection demonstrated 95% clinical categorical agreement. Aliquots plated ∼34 hours post-collection demonstrated 90% clinical categorical agreement. A 2% and 4% increase in organism recovery was observed in 34-hour non-preserved and preserved cultures, respectively, compared to 11 hours, with Enterococcus sp. being the most frequently recovered organism in both conditions. Loss of significant organisms occurred in 2% and 4% of non-preserved and preserved cultures, respectively, with Lactobacillus sp. showing the most decreased recovery in extended storage, regardless of preservative use. Conclusion The reformulated UriSponge device demonstrated strong bacteriostatic effectiveness in preserving urine samples collected at the clinic site and stored at room temperature, with high clinical categorical agreement when compared to refrigerated, unpreserved samples. The findings suggest that UriSponge is a reliable option for collecting and maintaining sample integrity, ensuring accurate uropathogen recovery in cases where delays in specimen processing occur.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».