Early treatment-related morbidity and mortality of children with non-Hodgkin’s lymphoma treated at Tikur Anbesa Specialized Hospital with modified ALCL protocol: prospective cohort study
Notice bibliographique
Résumé
BACKGROUND: Childhood non-Hodgkin lymphoma is a varied collection of malignant neoplasms that includes all lymphomas that are not categorized as Hodgkin lymphoma. It is the third most prevalent malignancy after leukemia and brain tumors. Over the last twenty years, significant improvements in chemotherapy combination, intensification, and supportive care have led to significant survival in high-income countries. However, in low- and middle-income countries, underlying malnutrition, delayed and advanced presentation, inadequate supportive care, and infection lead to poor overall outcomes and treatment-related early or late mortality; this study aimed to Assess, early induction phase treatment-related mortality and associated factors of children with non-Hodgkin's Lymphoma treated at Tikur Anbesa Specialized Hospital (TASH) treated with modified ALCL protocol. METHODS: A hospital-based Prospective cohort study design was conducted on a total of 50 children with confirmed non-Hodgkin's lymphoma treated at TASH from March 2023 to June 2024. data were collected using a structured questionnaire and entered into Epi Data 3.1 then exported to SPSS for analysis. The categorical variables in the study were presented using frequency, and percentage, and compared between groups using the chi-square test. Multivariate logistic regression analysis, cox proportional hazard ratio, and Kaplan Meier analysis were performed to analyze the survival and factors associated with early treatment-related mortality. RESULTS: The mean age at diagnosis was 5 years; abdominal swelling and constitutional symptoms like fever and weight loss were the common presenting complaints. Burkitt lymphoma accounts for 40% of the diagnosis and the majority of the patients present with advanced stage of the disease with elevated LDH (86%), and stage III/IV disease (92%). The majority of the patients had one or more oncologic emergencies at presentation the commonest being tumor lysis syndrome (TLS) (56%) and infection (32%). Infectious complications, hematologic toxicity, mucositis, and typhlitis were the commonly encountered chemotherapy-related toxicities and 24% of patients died during the induction phase. CONCLUSION: The induction phase of treatment resulted in a significantly high death rate (24%) for children and adolescents with NHL who were treated by the locally modified ALCL protocol.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».