PSVIII-10 The Impact of PROFORMIX|PET on gastrointestinal and metabolic health in puppies.
Notice bibliographique
Résumé
Abstract Weaning is psychologically and physiologically stressful. The psychological impact has been shown to increase the physiological stress response, alter immune function, and impact intestinal morphology and integrity. These physiological changes may create health challenges and diarrhea that may have lasting impacts throughout the lifespan. As a result, the use of supplements by puppy pet parents is on the rise to help combat gastrointestinal distress. PROFORMIX|PET (Probiotech International Inc.), a proprietary blend of tributyrin and polyphenols, has been shown to reduce inflammation post-exercise in dogs. Therefore, the objective of the current study was to evaluate gastrointestinal, metabolic, and immune markers in puppies. Twenty Labrador Retriever puppies (16-18 weeks; 2 litters; BWT:15.6±1.38kg) were blocked by litter, sex, and body weight and allocated to two treatments for the 30-day trial: Control- PureVitaTM grain-free turkey and sweet potato for all life stages (Nutrisource®, KLN Family Brands) fed to manufacturer’s recommendations or Treatment- Control plus 500mg PROFORMIX|PET per day. Puppies were blocked by litter, sex, age and weight. Physical wellness parameters were examined throughout the trial including body weight, stool quality and a clinical assessment. Immune, metabolic, and gastrointestinal health parameters were assessed at day 0 and 30. Statistical analysis was performed in SASv9.3 with a PROC MIXED and repeated measures. In cases where both a time and treatment main effect were found significant, contrasts were performed to compare simple effect differences of time within treatment. There was no impact (P>0.05) of treatment*time, treatment or time on stool scores and clinical assessments; all puppies were clinically healthy. Body weight increased (P< 0.0001) with time in both treatments (BWT d30: Control:20.6; Treatment:20.8±0.34kg). Although treatment*time was not significant, there was an impact of treatment (P=0.0003) and time (P=0.002) on CRP. When the time effect was compared within treatment, there was a more significant decline (-66%; P=0.0009) compared to control (-52%; P=0.06) from d0 to 30. Insulin was not affected by treatment*time (P=0.44) or treatment (P=0.26) but declined with time (P=0.04) in both groups. However, there was a treatment*time effect (P=0.03) on glucose with an increase at day 30 in control puppies (105.1±1.0mg/dL) and a decrease in treatment puppies (101.1±1.0mg/dL). This may indicate that PROFORMIX|PET has an impact on insulin efficiency, but more research is warranted. Fecal a1-PI, a marker of intestinal integrity, decreased with time (P< 0.0001) as expected with aging; however, there was a greater decline (-56%, P< 0.0001) in treatment puppies compared to control puppies (-46%, P =0.04) when the time effect was evaluated within treatment. There was no effect of treatment*time (P=0.44) or treatment (P=0.66) on fecal a1-PI. This initial evaluation of PROFORMIX|PET in puppies demonstrated positive impacts on puppy wellness. More research is warranted to confirm these initial findings.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».