The correlation between inflammatory biomarkers and vascular cognitive impairment in patients with cerebral small vessel disease
Notice bibliographique
Résumé
Objective: To investigate the correlation between plasma inflammatory biomarkers MMP-9, Lp-PLA2, IL-6, TNF-α and vascular cognitive impairment in patients with cerebral small vessel disease (CSVD), and to provide theoretical evidence for the early diagnosis and treatment of cognitive impairment in patients with cerebral small vessel disease. Methods: A total of 400 patients admitted to the Department of Neurology, Xuzhou Central Hospital, for treatment of CSVD from January 2019 to June 2023 were randomly selected. The cognitive function of the patients was assessed using the Montreal Cognitive Assessment (MoCA) scale. Based on the scores, the patients with CSVD were divided into a normal cognition group (n=196) and a cognitive impairment group (n=204). According to the severity of cognitive impairment, the cognitive impairment group was further divided into mild cognitive impairment group (n=100), moderate cognitive impairment group (n=59),and severe cognitive impairment group (n=45). A healthy control group of 100 individuals who underwent physical examinations during the same period was included. The correlation between plasma inflammatory biomarkers MMP-9, Lp-PLA2, IL- 6, TNF-α and vascular cognitive impairment was studied. Results: Compared with the healthy control group, the levels of smoking, homocysteine (HCY), carotid artery plaque formation, MMP-9, Lp-PLA2, IL-6, TNF-α in the normal cognition group and cognitive impairment group of patients with CSVD were significantly increased, with statistical significance (P<0.05). Moreover, the levels of smoking, HCY, carotid artery plaque formation, MMP-9, Lp-PLA2, IL-6, TNF-α in the cognitive impairment group were higher than those in the normal cognition group, with statistical significance (P<0.05). Multivariate logistic regression analysis showed that after controlling for confounding factors such as smoking, HCY, and carotid artery plaque formation, MMP-9, Lp-PLA2, IL-6, and TNF-α in patients with CSVD were still positively correlated with vascular cognitive impairment (P<0.05) and were independent risk factors. Compared with the mild cognitive impairment group, the levels of plasma MMP-9, Lp-PLA2, IL-6, and TNF-α in patients with moderate and severe cognitive impairment were significantly increased, with statistical significance (P<0.05); compared with the moderate cognitive impairment group, the levels of plasma MMP-9, Lp-PLA2, IL-6, and TNF-α in patients with severe cognitive impairment were significantly increased, with statistical significance (P<0.05). There was a negative linear relationship between plasma inflammatory biomarkers MMP-9, Lp-PLA2, IL-6, and TNF-α levels and cognitive function scores (P<0.05). Conclusion: Plasma MMP-9, Lp-PLA2, IL-6, and TNF-α are independent risk factors for vascular cognitive impairment in patients with CSVD. Plasma MMP-9, Lp-PLA2, IL-6, and TNF-α levels in patients with CSVD are positively correlated with the severity of vascular cognitive impairment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».