Changes in peripheral blood and cognitive performance after nonconcussive head impacts in elite female soccer players
Notice bibliographique
Résumé
Exposure to repetitive head impacts (RHI) has been shown to be associated with cognitive impairment and markers of neurodegeneration in professional male soccer players. However, data on the effects of RHI in female players are very limited. In this exploratory study, we investigated changes in blood biomarkers along with the cognitive status of elite female soccer players and compared the effect of RHI with outcomes in male players. In a cohort study, elite female soccer players (age 16–41 years) performed training without heading the ball (n = 36) and training including heading (n = 30). Athletes were evaluated for the parameters of physical activity (heart rate) and neuropsychological testing (focused attention and cognitive flexibility) before and 1 h after each training. The levels of plasma tau, pTau181, pTau217 and microRNAs were determined at four timepoints: before training, 1 h, 24 h, and 48 h after each training session. Parameters in females were compared with control male players (n = 32). The levels of tau, pTau181 and pTau217 are significantly increased in the plasma of female soccer players 1 hour after physical exercise (tau, 1.4-fold; pTau181, 1.3-fold; pTau217, 1.2-fold) and repetitive head impacts (tau, 1.2-fold; pTau181, 1.3-fold; pTau217, 1.3-fold) compared to pre-training levels. The ratio of pTau181 to tau fold change is significantly higher 1 hour after heading and remains elevated specifically in the heading group even after 48 h. The analysis of deregulated microRNAs in plasma reveals enrichment of neuroprotective pathways after heading training. Female soccer players show worse cognitive functions after heading compared to exercise and also compared to male soccer players. RHIs may lead to acute disbalance of tau and phosphorylated tau in plasma, and are associated with short-term decline in cognitive performance and neuroprotective pathways in elite female soccer players. The sexual dimorphism in response to RHI may reflect biological risk factors potentially relevant to the different degree of susceptibility to neurological disorders in females and males in later life. Majority of neuroscience research is conducted on male subjects, creating a gap in the knowledge. Here we investigated the effect of repetitive non-concussive head impacts (RHI) in elite female soccer players. The athletes were evaluated for the parameters of physical activity, cognition and levels of plasma tau protein which are known biomarkers of neurodegeneration. Our data demonstrate that repetitive heading of the ball is associated with biochemical alterations, reduction in focused attention, and cognitive flexibility. Here we also show that females are more sensitive to head impacts when compared to males and that the RHI exposure is associated with neuroprotective signaling. These findings link specific molecular pathways, potentially operating in the early stage of brain diseases. Deeper exploration of these pathways could be a promising approach to identify new biomarkers and therapeutic targets in the treatment of neurodegeneration. Cente et al. investigate the acute effects of mild repetitive head impacts in female soccer players. Findings reveal that female players are more sensitive to head impacts compared to males, as manifested by short-term decline in cognitive performance, altered plasma tau protein profile, and initiation of neuroprotective pathways.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».