A plain language summary of LocoMMotion – an observational study of treatments used for pretreated multiple myeloma
Notice bibliographique
Résumé
Plain Language SummaryWhat is this summary about?This is a Plain Language Summary of Publication of the LocoMMotion study, an observational study in which researchers monitored patients living with multiple myeloma and the treatments that they received in real-world clinical practice. LocoMMotion studied patients with relapsed/refractory multiple myeloma who were triple-class exposed. The researchers wanted to find out how well patients responded to different types of treatment over a 2-year follow-up period.What were the results?In total, 248 patients with relapsed/refractory multiple myeloma were enrolled in the study from August 2, 2019 until October 26, 2020. During the study, 91 different types of treatment were used, which shows the lack of standard treatment for patients with triple-class exposed relapsed/refractory multiple myeloma. Nearly one third of patients (31.9%) had a positive response (i.e. the number of tumor cells reduced), to the first treatment they received after enrolling in this study. Half of patients responded to treatment for at least 7.4 months.Overall, half of patients in the study remained alive for at least 13.8 months. Just over half of the patient group (53.4%) were alive one year into the study. Overall, 63.7% of patients did not survive during the study, mainly due to their cancer getting worse, which occurred in 67.7% of these cases. In total, 8.5% of patients had at least one side effect that resulted in death, most commonly due to infections (5.2%). Based on responses to a questionnaire about their treatment and symptoms,patients said that the current treatments did not noticeably improve their quality of life. For example, 53.3% of patients did not have any meaningful improvement in pain during treatment.What do the results mean?In this study, most patients with relapsed/refractory multiple myeloma did not have a long-lasting response to treatment, and many patients received subsequent therapies after the initial study therapy. Additionally, the many different treatments used show that there is not a standardized treatment for patients with triple-class exposed relapsed/refractory multiple myeloma. Lastly, the quality of patients’ lives did not improve much during their treatment, which highlights the need for new treatments. LocoMMotion was an observational and non-randomized study, so may have some limitations that mean data must be interpreted carefully. Some baseline patient information and laboratory assessments may have been missing, and the study did not have a comparative group.This is an abstract of the Plain Language Summary of Publication article.View the full Plain Language Summary PDF of this article to read the full-text
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,018 | 0,128 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,002 | 0,002 |
| Bibliométrie | 0,004 | 0,006 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,003 | 0,002 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,003 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,035 | 0,009 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».