#2541 Severity of preeclampsia and fetal complications—potential association with serum albumin levels?
Notice bibliographique
Résumé
Abstract Background and Aims Preeclampsia (PE) affects 5-8% of pregnancies worldwide. Recent studies have suggested that serum albumin and proteinuria are related to the severity of PE and its complications. The Canadian Society of Obstetrics and Gynecology suggested that a serum albumin level of 2 g/dl or less may represent one of the criteria of severity. The aim of the study was to assess the relevance of serum albumin level in the severity of preeclampsia, and its potential association with maternal and fetal complications. Method A descriptive and prospective study was used for analyzing the relevance of serum albumin level in the severity of preeclampsia, and its potential association with maternal and fetal complications, at a level less than 2 g/dL. Results The study group included 59 pregnant women with PE and depending on severity of preeclampsia were established 2 groups: 23 women with mild PE and 36 women with severe PE. Depending on the gestational age at onset of PE, the study groups were divided into 2 groups: early onset (<34 weeks) and late onset (>34 weeks). The risk of finding severe PE in pregnant women with early onset is 5.625 times higher than the risk of finding severe PE in pregnant women with late onset (OR = 5.625, 95% CI for OR = 1.794–17.633). Albumin levels were significantly different between the group with severe PE versus mild PE (2.44 ± 0.36, respectively 1.82 ± 0.50; t = −5.507, df = 56.381, P < 0.001). The Youden index was 0.6280, establishing a level of 2.3 g/dl which represents the threshold between the severe PE and the mild PE (sensitivity 88.89%, specificity 73.9%) We observed a strong association between albumin <2 g/dL and severe proteinuria. The risk of encountering the impairment of renal function, liver function and severe proteinuria/24 h in pregnant women with serum albumin >2 g/dL is considered equal to the risk of encountering impairment of renal function, liver function and severe proteinuria in patients with serum albumin <2 g/dL (Table 1).The risk of fetal complications, prematurity and low birth weight in pregnant women with serum albumin >2 (g/dL) is considered equal to the risk of fetal complications, prematurity and low birth weight in patients with serum albumin <2 (g/dL) (Table 2). There was no association of serum albumin level with gestational age, dysfunction of renal/hepatic function and proteinuria/24 h. (P > α = 0.05) or fetal complications, prematurity, and low birth weight of the new-born (P > α = 0.05) Conclusion Serum albumin was increased in the group of pregnant women with severe PE compared to mild PE. Serum albumin levels less than 2 g/dL are not mandatory to be included in the PE severity criteria, more studies are required. Prematurity and low birth weight are fetal complications frequently associated with PE, but could not be correlated with low value of serum albumin in pregnant women with PE.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,006 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».