DISTRACTION OSTEOGENESIS RECONSTRUCTION FOLLOWING RESECTION OF BONE SARCOMAS: A PROSPECTIVE COHORT STUDY
Notice bibliographique
Résumé
Biological reconstruction with distraction osteogenesis (DO) is an effective reconstructive method following resection for osseous sarcomas, particularly in the pediatric, adolescent and young adult population. Sustainable long-term function has been established, but there is a paucity of published data informing surgeons and patients on important milestones in the reconstructive process. The objectives of this study are to determine when to expect cortex formation, bone healing, and full weight bearing, as well as the influence of chemotherapy on the bony regeneration process. Prospectively, laboratory, clinical and patient reported outcome score (PROS) data was collected on 30 consecutive patients who underwent primary or secondary DO-based reconstruction following osseous resection at our tertiary care institution from 2018–2021. Serial radiographs indicated the time to cortex formation and full union. An unpaired t-test was used to compare the times required for full bone remodeling of primary and subsequent lengthening segments, and bone healing index (months required per cm of bone regenerated). Functional outcome metrics included the Musculoskeletal Tumor Society (MSTS), Time to Get Up and Go (TTGUG), and Toronto Extremity Salvage Scores (TESS). 7 males and 13 females were included. Median age at initiation of lengthening was 14 (range 4.5–56). Tumor subtypes included conventional high-grade osteosarcoma (16), Ewings sarcoma (6), UPS of bone (3), Adamantinoma (2), undifferentiated round cell sarcoma (BCOR-CCNB3) (2), and parosteal osteosarcoma (1). The average resection length was 13.6 cm (4–22). Resections were from 16 femurs, 11 tibias, 2 humeri and 1 radius. Patients underwent an average of 6.1 procedures (1–14). Half (50%) of all additional procedures were planned repeat lengthening procedures while half were unplanned (20% for infection, 16% for non-union or mal-union, 7% for fracture, 4% hardware failure, 2% for specific docking site issues, 2% for premature consolidation, and 1% for neuropraxia). The first lengthened segment, often initiated concurrently with chemotherapy, required an average of 17 months (+- 7.0) for full remodeling while subsequently lengthened segments, occurring after completion of systemic therapy, required an average of 8.6 months (+- 3.4) for full remodeling (p=.0002). The bone healing index improved from 2.1 to 1.1 months per cm of regenerate bone if no chemotherapy was administered concurrently (p<0.0001). All patients achieved full independent weight bearing and median time to full weight bearing was 12 months (IQR 9–16). Final functional outcomes scores were 24.2 (+−4.8) for MSTS and 81.5 (+−11.5) for TESS, and 7.9s (+−1.9) for TTGUG. This is the largest reported series of distraction osteogenesis reconstruction in oncological patients. Our cohort, similarly to other reported series in the literature, demonstrated a relatively high rate of unplanned returns to the operating room. Despite the increased complications, DO reconstruction remains an attractive option for autologous bone regeneration after massive bony resections for sarcoma. Surgeons and patients can expect bone healing to be nearly twice as fast for segments occurring after completion of systemic chemotherapy compared to segments initiated concurrently with adjuvant chemotherapy.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».