Epidemiology and Treatment Outcomes of Pulmonary Tuberculosis in Dazu District, Chongqing, China, 2005-2024: Surveillance Study
Notice bibliographique
Résumé
Background: As a high tuberculosis (TB) burden area in China, Dazu District of Chongqing Municipality contains a large rural population and exhibits typical features of TB endemicity. Objective: This study aimed to analyze the epidemiological characteristics and treatment outcomes of pulmonary tuberculosis (PTB) in Dazu District from 2005 to 2024, with the aim of supporting the optimization of regional TB control strategies. Methods: Data on PTB cases in Dazu District from 2005 to 2024 were collected from the China Disease Control and Prevention Information System. Descriptive epidemiological methods were employed to analyze the temporal, demographic, and geographical distributions, along with trends in treatment outcomes. Global and local spatial autocorrelation analyses were performed using Moran I and Getis-Ord Gi* statistics, respectively. Results: A total of 10,236 cases were reported, for an average annual notification incidence of 65.2 per 100,000 population. The annual average notification incidence decline rate was 7.7%. Joinpoint regression analysis revealed a statistically significant decline in annual incidence rates (average annual percent change=-6.81, 95% CI -7.25 to -6.30, P<.0001). The bacteriological positivity rate initially decreased before rising, reaching 81.6% in 2024. Reported case counts peaked in March, while relatively lower numbers were observed during October, November, and December. Cases were predominantly among male patients, with a male-to-female ratio of 3.57:1. The case composition ratio in the ≥65 years age group has gradually increased, from 13.8% in 2006 to 19.9% in 2015 and to 38.5% in 2024. Occupational distribution was primarily among farmers (77.6%, 7948/10,236), homemakers or unemployed individuals (5.6%, 570/10,236), and students (3%, 303/10,236). Cases were concentrated in Longshui Town (13.1%, 1339/10,236), Tangxiang Subdistrict (9.1%, 933/10,236), and Longgang Subdistrict (7.9%, 811/10,236)-areas with large population bases. Among these, Guoliang Town exhibited the highest average annual notification incidence (314.4/100,000). Treatment success rate reached 91.3%. Multivariate binary logistic regression revealed that age 25-44 years (OR 1.755; 95% CI 1.320-2.332; P<.0001), undergoing initial treatment (OR 3.786; 95% CI 2.524-5.680; P<.0001), absence of HIV coinfection (OR 2.499; 95% CI 1.714-3.643; P<.0001), negative bacteriologic test results (OR 2.841; 95% CI 2.214-3.646; P<.0001), and the receipt of full-course supervised treatment (OR 7.705; 95% CI 4.520-13.137; P<.0001) were significantly associated with treatment success. Conclusions: The notification incidence of PTB in Dazu District, Chongqing, has gradually declined. Particular focus is required on the treatment of young children, elderly individuals, patients with HIV coinfection, those under intensive phase supervision, bacteriologically positive cases, and retreatment cases. These measures may reduce the incidence of PTB and improve treatment success rates in our district.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,002 | 0,002 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».