Role of Candida in the Pathogenesis of Oral Squamous Cell Carcinoma: A Systematic Review
Notice bibliographique
Résumé
Introduction: Oral Squamous Cell Carcinoma (OSCC) is the sixteenth most prevalent cancer globally, with a significant proportion of cases originating in India. The progression from healthy oral mucosa to OSCC often involves Oral Potentially Malignant Disorders (OPMDs). However, recent classification updates have excluded chronic candidiasis from the list of OPMDs. Despite this, Candida species are frequently associated with cases of severe dysplasia and OSCC, suggesting a potential role in the pathogenesis of OSCC. By exploring specific pathways through which Candida may promote carcinogenesis, this review highlights the importance of recognising chronic candidiasis as an OPMD for early diagnosis and improved patient outcomes. Aim: The present systematic review aimed to consolidate evidence on the potential association between chronic Candida infections and the pathogenesis of OSCC. Materials and Methods: The present systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Original studies involving tumour tissues or archival blocks from patients with oral cancer and those addressing OSCC pathogenesis were included; case reports, case series, and studies using only saliva samples or oral swabs were excluded. A comprehensive search across PubMed, Scopus, and Web of Science was performed up to December 10, 2023. Study quality was assessed using the Newcastle-Ottawa Scale, with modifications to fit the review’s objectives. Data extraction included information on Candida species and diagnostic approaches, with results synthesised narratively due to variability among studies. Results: The search strategy yielded 624 articles from multiple databases (PubMed: 263; Scopus: 204; Web of Science: 157). After applying the inclusion and exclusion criteria, only 13 studies were selected for the review. Candida prevalence in Oral Leukoplakia (OL) ranged from 6.8 to 100%, with three studies reporting malignant transformation rates of 2.5%, 6.5%, and 28.7%. C. albicans was the most frequently detected species, followed by C. dubliniensis, C. glabrata, C. guilliermondii, and C. krusei. Some studies identified additional fungal species, though they were considered potential contaminants. Histological analysis revealed Candida hyphae penetrating deep into OSCC tissues, suggesting a role in tumour progression. Conclusion: The review highlights the importance of recognising chronic candidiasis as an OPMD due to its potential role in the pathogenesis of OSCC. Early identification and management of chronic Candida infections could serve as a preventive strategy in high-risk populations. The findings advocate for the inclusion of chronic candidiasis in future classifications of OPMDs to enhance early diagnosis and improve patient outcomes.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,011 | 0,021 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».