Clinical characteristics of pediatric epilepsy in Palestine: a cross-sectional study
Notice bibliographique
Résumé
BACKGROUND: Epilepsy, a prevalent neurological disorder in children, is characterized by recurrent unprovoked seizures and developmental challenges. Although pediatric epilepsy is well-studied globally, research in Palestine is limited, which affects targeted healthcare interventions. Furthermore, socioeconomic barriers and limited resources make it difficult to manage epilepsy locally. This study addresses the clinical, diagnostic, and therapeutic aspects of pediatric epilepsy in Palestine to inform evidence-based healthcare planning and improve outcomes for affected children. METHODS: A retrospective cross-sectional study was conducted between December 2023 and October 2024, analyzing medical records of 411 pediatric epilepsy patients (aged 2 months to 18 years) diagnosed between 2019 and 2024 at two major pediatric neurology clinics in the West Bank. The data on demographics, seizure types, diagnostic tools, etiology, comorbidities, and treatment approaches were collected retrospectively. The statistical analysis was conducted using IBM SPSS version 24, which employed both descriptive and analytical statistics to identify associations. RESULTS: Of the 411 patients, 67.2% were male, and 38.3% were school-age children at the time of seizure onset. Focal seizures were the most common type (62.8%). Among epilepsy syndromes, self-limited epilepsy with centrotemporal spikes (SeLECTs) was the most frequently identified (10.9%). The etiology was unknown in 53.8% of cases; genetic and structural causes were identified in 7.3% and 13.6%, respectively. Monotherapy was used in 62% of patients, including 71.6% of those without comorbidities. A statistically significant association was found between the number of antiseizure medications (ASMs) and the presence of comorbidities (p = 0.001), with patients without comorbidities more likely to receive monotherapy. Significant correlations were also identified between seizure type and age of onset (p = 0.000), etiology (p = 0.001), and type of comorbidities (excluding mood disorders). Drug-resistant epilepsy affected 3.4% of patients and was significantly associated with younger age at seizure onset (p = 0.042), cognitive and developmental comorbidities (p < 0.05), and genetic etiology (p = 0.02). Only 1% of patients received surgical intervention, and none were treated with ketogenic diets. CONCLUSION: This study focused on the clinical characteristics of pediatric epilepsy and highlighted the challenges associated with the availability of treatment modalities, advanced diagnostic tools such as genetic testing, and the limited use of dietary and surgical interventions in Palestine.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».