167 Assessment of pathologic complete response following neoadjuvant therapy in patients with resectable lung cancer is equivalent across scoring systems
Notice bibliographique
Résumé
Background Neoadjuvant/perioperative chemoimmunotherapy is a standard of care for treating patients with resectable non-small lung cancer (NSCLC) based on several phase III registrational clinical trials demonstrating improvement in rates of pathologic complete response (pCR, 0% residual viable tumor, RVT, in the resection specimen), event-free survival (EFS), and overall survival (OS) in patients treated with chemoimmunotherapy vs chemotherapy alone. However, pathologic response assessment criteria varied amongst these trials, with some studies reporting scoring by pan-tumor pathologic response criteria (irPRC) described in 2018 1 and others using criteria described by the International Association for the Study of Lung Cancer published in 2020.2 Despite the fact that these criteria are very similar in their approach to pathologic response assessment, some investigators have questioned whether cross-trial differences exist with regard to the value of pCR due to the different scoring systems used. The purpose of this study was to determine whether pCR assessed by these two scoring systems was associated with differential pCR rates across these trials and/or predictive value in the form of hazard ratios (HR) for the association of pCR with EFS.Methods A literature review was performed to identify phase III trials in patients with resectable NSCLC treated with chemoimmunotherapy in the neoadjuvant/perioperative setting. pCR rates and HR of pCR for predicting EFS were extracted from each trial manuscript. If the latter was not provided, data from the published Kaplan-Meier survival curves were converted to patient-level data using R package IPDfromKM with iterative Kaplan-Meier method3 and a HR was calculated.Results Five trials met criteria for inclusion 4–8 (table 1). All studies defined pCR as 0% RVT in both the primary tumor and lymph nodes. pCR rates across these studies were similar (range 17-25%). HRs for pCR predicting EFS were also comparable (range 0.13-0.16; table 1), indicating that pCR as assessed by either method had similar associations with EFS.Conclusions Regardless of criteria used for assessment of pCR, equivalent rates of pCR and HRs measuring the association between pCR and EFS were found across five phase III registrational trials in patients with resectable lung cancer treated with neoadjuvant/perioperative chemoimmunotherapy. This finding thus supports meta-analyses assessing the association between pCR and EFS.References Cottrell TR, Thompson ED, Forde PM, Stein JE, Duffield AS, Anagnostou V, et al. Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small-cell lung carcinoma: a proposal for quantitative immune-related pathologic response criteria (irPRC). Ann Oncol. 2018 Aug 1;29(8):1853–1860.Travis WD, Dacic S, Wistuba I, Sholl L, Adusumilli P, Bubendorf L, et al. IASLC multidisciplinary recommendations for pathologic assessment of lung cancer resection specimens after neoadjuvant therapy. J Thorac Oncol. 2020 May;15(5):709–740.Liu N, Zhou Y, Lee JJ. IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves. BMC Med Res Methodol. 2021 Jun 1;21(1):111.Heymach JV, Harpole D, Mitsudomi T, Taube JM, Galffy G, Hochmair M, et al. Perioperative durvalumab for resectable non-small-cell lung cancer. N Engl J Med. 2023 Nov 2;389(18):1672–1684.Cascone T, Awad MM, Spicer JD, He J, Lu S, Sepesi B, et al. Perioperative nivolumab in resectable lung cancer. N Engl J Med. 2024 May 16;390(19):1756–1769.Forde PM, Spicer J, Lu S, Provencio M, Mitsudomi T, Awad MM, et al. Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer. N Engl J Med. 2022 May 26;386(21):1973–1985.Wakelee H, Liberman M, Kato T, Tsuboi M, Lee SH, Gao S, et al. Perioperative pembrolizumab for early-stage non-small-cell lung cancer. N Engl J Med. 2023 Aug 10;389(6):491–503.Lu S, Zhang W, Wu L, Wang W, Zhang P; Neotorch Investigators. Perioperative toripalimab plus chemotherapy for patients with resectable non-small cell lung cancer: the neotorch randomized clinical trial. JAMA. 2024 Jan 16;331(3):201-211.Abstract 167 Table 1Phase III trials investigating neoadjuvant/perioperative chemoimmunotherapy in NSCLCpCR = pathologic complete response; HR = hazard ratio, EFS = event-free survival; CI = confidence interval; chemo = chemotherapy; IASLC = International Association for the Study of Lung Cancer; irPRC = pan-tumor pathologic response criteria*HR and/or survival curves by pathologic response not published
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,008 | 0,027 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,001 |
| Bibliométrie | 0,002 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,002 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».