Utilization and Feasibility of a Wearable Device in Patients With Sedative Effects of Drugs: Protocol for a Prospective Observational Study for the Advanced Respiratory Monitoring Events in Drug Toxicity (ARM-ED) Study
Notice bibliographique
Résumé
Background: Drug-related deaths worldwide are most commonly attributed to opioids. Opioids and other sedative drugs can cause respiratory depression and airway compromise, leading to hypoxia and death. Device technology and artificial intelligence used to detect drug overdose has the potential to improve outcomes. PneumoWave Ltd has developed a small chest-worn respiratory monitoring device to detect concerning breathing patterns and alert an emergency response. Objective: The aim of this study is to investigate the feasibility of using the PneumoWave device in hospital patients at risk of respiratory depression. Methods: This 18-month prospective observational study was performed at the Queen Elizabeth University Hospital, Glasgow. The study investigates the use of the device on 3 groups of patients at risk of respiratory depression due to drugs. This includes patients attending the emergency department (ED) due to sedative drug overdose, patients receiving procedural sedation and analgesia in the ED, and patients receiving general anesthesia in theaters. Consenting participants will have the PneumoWave sensor paired with end-tidal CO2 monitoring and regular recordings of vital signs. Usability will be tested by administering a questionnaire to the patient, the clinician, and the nurse. The primary end point is to determine the feasibility of gathering respiratory data from a wearable respiratory monitoring device in the ED. Statistical analysis includes comparison of biosensor data against reference physiology time course data. Results: Trial recruitment was completed on December 8, 2023. Twenty-five patients were enrolled in group 1 (acute toxicity); 39 patients in group 2 (procedural sedation), including 1 patient who was subsequently withdrawn; and 14 patients in group 3 (acute toxicity), with 2 patients withdrawn. Publication of the study results is anticipated by December 2025. Conclusions: This study will explore the feasibility of the PneumoWave device in a variety of clinical contexts in which risk of pharmacologically induced respiratory depression is present. This will provide valuable insight into the use of device technology in individuals at risk of illicit drug-related harm within the relative safety of a hospital setting. A limitation of the study procedure is exclusion of patients with intoxication after sedative drug overdose who lack the capacity to provide informed consent. This study has been designed to acquire feasibility data to demonstrate the potential for continuous respiratory monitoring to improve outcomes for patients who are at risk of drug-induced respiratory depression, inform product development, and inform the design of future pivotal clinical investigations.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».