The effectiveness of dual task training when combined with exercise on cognition in individuals with Parkinson’s disease: a randomized clinical trial
Notice bibliographique
Résumé
Background: Cognitive decline is among the most frequent non-motor symptoms of Parkinson’s disease (PD). This decline affects daily activities, gait, postural control, and the ability to perform dual tasks (DT). Managing PD, especially its non-motor symptoms, is challenging, leading to a growing interest in studies investigating the effectiveness of various treatment protocols, whether isolated or combined. Objective: To verify the effectiveness of dual task training when combined with walking on a treadmill as well as anodal transcranial direct current stimulation (tDCS) on cognition in individuals with PD. Methods: This study is a randomized, controlled, blinded clinical trial involving 36 individuals with mild to moderate PD without cognitive decline. Participants were divided into two groups: 1) the Experimental Group (EG): underwent dual task training + walking on a treadmill + anodal tDCS and 2) the Control Group (CG): underwent walking on a treadmill + anodal tDCS. There were 12 intervention sessions, that were conducted three times a week. The dual task training protocol consisted of three levels, with six tasks per level, progressively increasing in complexity, and was applied for 18 minutes while walking on a treadmill. The current was applied to the left dorsolateral prefrontal cortex at an intensity level of 2mA, while walking on a treadmill. A cognitive assessment was conducted using the Montreal Cognitive Assessment (MoCA), the Trail Making Test, and the Stroop Test. Evaluations were performed three times at different points: pre-intervention, post-intervention, and after a 4-week follow-up period. Repeated measures ANOVA was used to compare the groups based on intervention, time, and group-time interaction. The study was approved by the Ethics Committee (CAAE: 30668420.7.0000.5188) and registered at Clinical Trials (NCT04581590). Results: There was a significant improvement in cognition in the EG (time effect) between pre- and post-intervention, and between pre-intervention and follow-up in the delayed recall domain and the total MoCA score. Additionally, there was improvement from pre-intervention to follow-up in the Stroop Test performance. For the CG, there was improvement between pre- and post-intervention in the Stroop Test performance, and between pre-intervention and follow-up in the delayed recall domain of the MoCA. No differences were observed between groups or in the time vs. group interaction. Conclusion: The addition of dual task training to a combined walking on a treadmill and anodal tDCS protocol was not effective in improving cognition in individuals with PD. Cognition is a complex construct, and more studies are needed to advance this investigation and seek an optimal protocol based on the type, number of sessions, frequency, duration, and intensity of the intervention to aid clinical decision-making.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,006 | 0,003 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,003 | 0,002 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,005 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».